Chromatin accessibility: methods, mechanisms, and biological insights
AR Mansisidor, VI Risca - Nucleus, 2022 - Taylor & Francis
Access to DNA is a prerequisite to the execution of essential cellular processes that include
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …
[HTML][HTML] The role of EZH1 and EZH2 in development and cancer
SH Lee, Y Li, H Kim, S Eum, K Park, CH Lee - BMB reports, 2022 - ncbi.nlm.nih.gov
Abstract Polycomb Repressive Complex 2 (PRC2) exhibits key roles in mammalian
development through its temporospatial repression of gene expression. EZH1 or EZH2 is the …
development through its temporospatial repression of gene expression. EZH1 or EZH2 is the …
Polycomb repression of Hox genes involves spatial feedback but not domain compaction or phase transition
SE Murphy, AN Boettiger - Nature genetics, 2024 - nature.com
Polycomb group proteins have a critical role in silencing transcription during development. It
is commonly proposed that Polycomb-dependent changes in genome folding, which …
is commonly proposed that Polycomb-dependent changes in genome folding, which …
Gain and loss of function variants in EZH1 disrupt neurogenesis and cause dominant and recessive neurodevelopmental disorders
Genetic variants in chromatin regulators are frequently found in neurodevelopmental
disorders, but their effect in disease etiology is rarely determined. Here, we uncover and …
disorders, but their effect in disease etiology is rarely determined. Here, we uncover and …
Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1
Histone H2A lysine 119 (H2AK119Ub) is monoubiquitinated by Polycomb repressive
complex 1 and deubiquitinated by Polycomb repressive deubiquitinase complex (PR-DUB) …
complex 1 and deubiquitinated by Polycomb repressive deubiquitinase complex (PR-DUB) …
PRC2, chromatin regulation, and human disease: insights from molecular structure and function
X Liu, X Liu - Frontiers in Oncology, 2022 - frontiersin.org
Polycomb repressive complex 2 (PRC2) is a multisubunit histone-modifying enzyme
complex that mediates methylation of histone H3 lysine 27 (H3K27). Trimethylated H3K27 …
complex that mediates methylation of histone H3 lysine 27 (H3K27). Trimethylated H3K27 …
EZH1/2 as targets for cancer therapy
R An, YQ Li, YL Lin, F Xu, MM Li, Z Liu - Cancer Gene Therapy, 2023 - nature.com
The enhancer of zeste homolog 2 (EZH2) and its highly related homolog EZH1 are
considered to be epigenetic silencing factors, and they play key roles in the growth and …
considered to be epigenetic silencing factors, and they play key roles in the growth and …
Activation of automethylated PRC2 by dimerization on chromatin
PV Sauer, E Pavlenko, T Cookis, LC Zirden, J Renn… - Molecular Cell, 2023 - cell.com
Summary Polycomb repressive complex 2 (PRC2) is an epigenetic regulator that
trimethylates lysine 27 of histone 3 (H3K27me3) and is essential for embryonic development …
trimethylates lysine 27 of histone 3 (H3K27me3) and is essential for embryonic development …
DNA binding by polycomb-group proteins: searching for the link to CpG islands
BM Owen, C Davidovich - Nucleic Acids Research, 2022 - academic.oup.com
Polycomb group proteins predominantly exist in polycomb repressive complexes (PRCs)
that cooperate to maintain the repressed state of thousands of cell-type-specific genes …
that cooperate to maintain the repressed state of thousands of cell-type-specific genes …
Distinct accessory roles of Arabidopsis VEL proteins in Polycomb silencing
E Franco-Echevarría, M Nielsen… - Genes & …, 2023 - genesdev.cshlp.org
Abstract Polycomb repressive complex 2 (PRC2) mediates epigenetic silencing of target
genes in animals and plants. In Arabidopsis, PRC2 is required for the cold-induced …
genes in animals and plants. In Arabidopsis, PRC2 is required for the cold-induced …