[HTML][HTML] Calcium signaling regulates autophagy and apoptosis

P Sukumaran, V Nascimento Da Conceicao, Y Sun… - Cells, 2021 - mdpi.com
Calcium (Ca2+) functions as a second messenger that is critical in regulating fundamental
physiological functions such as cell growth/development, cell survival, neuronal …

[HTML][HTML] Autophagy and neurodegeneration: pathogenic mechanisms and therapeutic opportunities

FM Menzies, A Fleming, A Caricasole, CF Bento… - Neuron, 2017 - cell.com
Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for
degradation. Here we consider its roles in neuronal health and disease. We review …

[HTML][HTML] The cellular phase of Alzheimer's disease

B De Strooper, E Karran - Cell, 2016 - cell.com
The amyloid hypothesis for Alzheimer's disease (AD) posits a neuron-centric, linear cascade
initiated by Aβ and leading to dementia. This direct causality is incompatible with clinical …

Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology

EE Spangenberg, RJ Lee, AR Najafi, RA Rice… - Brain, 2016 - academic.oup.com
In addition to amyloid-β plaque and tau neurofibrillary tangle deposition, neuroinflammation
is considered a key feature of Alzheimer's disease pathology. Inflammation in Alzheimer's …

[HTML][HTML] Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: pathogenic mechanisms and therapeutic potential

W Zhang, C Xu, J Sun, HM Shen, J Wang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Abstract Alzheimer's disease (AD), the most common neurodegenerative disorder, is
characterized by memory loss and cognitive dysfunction. The accumulation of misfolded …

Compromised autophagy and neurodegenerative diseases

FM Menzies, A Fleming, DC Rubinsztein - Nature Reviews …, 2015 - nature.com
Most neurodegenerative diseases that afflict humans are associated with the
intracytoplasmic deposition of aggregate-prone proteins in neurons and with mitochondrial …

Autophagy induction as a therapeutic strategy for neurodegenerative diseases

A Djajadikerta, S Keshri, M Pavel, R Prestil… - Journal of molecular …, 2020 - Elsevier
Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic
contents to lysosomes for degradation. Genetic studies have revealed extensive links …

[HTML][HTML] What is the evidence that tau pathology spreads through prion-like propagation?

A Mudher, M Colin, S Dujardin, M Medina… - Acta neuropathologica …, 2017 - Springer
Emerging experimental evidence suggests that the spread of tau pathology in the brain in
Tauopathies reflects the propagation of abnormal tau species along neuroanatomically …

[HTML][HTML] Autophagy in neurodegenerative diseases: a hunter for aggregates

H Park, JH Kang, S Lee - International Journal of Molecular Sciences, 2020 - mdpi.com
Cells have developed elaborate quality-control mechanisms for proteins and organelles to
maintain cellular homeostasis. Such quality-control mechanisms are maintained by …

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

Z Zhao, AP Sagare, Q Ma, MR Halliday, P Kong… - Nature …, 2015 - nature.com
PICALM is a highly validated genetic risk factor for Alzheimer's disease (AD). We found that
reduced expression of PICALM in AD and murine brain endothelium correlated with amyloid …