FM Menzies, A Fleming, A Caricasole, CF Bento… - Neuron, 2017 - cell.com
Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for degradation. Here we consider its roles in neuronal health and disease. We review …
The amyloid hypothesis for Alzheimer's disease (AD) posits a neuron-centric, linear cascade initiated by Aβ and leading to dementia. This direct causality is incompatible with clinical …
EE Spangenberg, RJ Lee, AR Najafi, RA Rice… - Brain, 2016 - academic.oup.com
In addition to amyloid-β plaque and tau neurofibrillary tangle deposition, neuroinflammation is considered a key feature of Alzheimer's disease pathology. Inflammation in Alzheimer's …
W Zhang, C Xu, J Sun, HM Shen, J Wang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Abstract Alzheimer's disease (AD), the most common neurodegenerative disorder, is characterized by memory loss and cognitive dysfunction. The accumulation of misfolded …
FM Menzies, A Fleming, DC Rubinsztein - Nature Reviews …, 2015 - nature.com
Most neurodegenerative diseases that afflict humans are associated with the intracytoplasmic deposition of aggregate-prone proteins in neurons and with mitochondrial …
Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic contents to lysosomes for degradation. Genetic studies have revealed extensive links …
Emerging experimental evidence suggests that the spread of tau pathology in the brain in Tauopathies reflects the propagation of abnormal tau species along neuroanatomically …
H Park, JH Kang, S Lee - International Journal of Molecular Sciences, 2020 - mdpi.com
Cells have developed elaborate quality-control mechanisms for proteins and organelles to maintain cellular homeostasis. Such quality-control mechanisms are maintained by …
Z Zhao, AP Sagare, Q Ma, MR Halliday, P Kong… - Nature …, 2015 - nature.com
PICALM is a highly validated genetic risk factor for Alzheimer's disease (AD). We found that reduced expression of PICALM in AD and murine brain endothelium correlated with amyloid …