Abstract Treatment of bone and joint infections can be challenging as antibiotics should
penetrate through the rigid bone structure and into the synovial space. Several …

The standard recommendation for treating chronic osteomyelitis is 6 weeks of parenteral
antibiotic therapy. However, oral antibiotics are available that achieve adequate levels in …

Purpose An understanding of the pharmacokinetic (PK) and pharmacodynamic (PD)
principles that determine response to antimicrobial therapy can provide the clinician with …

Chronic osteomyelitis is a challenging disease due to its serious rates of mortality and
morbidity while the currently available treatment strategies are suboptimal. In contrast to the …

Antibacterials play a key role in the treatment of bone infections and appropriate surgical
prophylaxis. The rate and extent of penetration of antimicrobials into bone has been …

Chronic osteomyelitis is a major challenge in bone surgery. Conventional use of antibiotics
is not an effective way to control the malaise due to so many reasons. Determination of …

The aim of our study was to evaluate the outcome of acute prosthetic joint infections (PJIs)
due to gram-negative bacilli (GNB) treated without implant removal. Patients with an acute …

Background: P. aeruginosa implant-associated bone and joint infections (BJI) is considered
to be one of the most difficult to treat BJI. The data focusing specifically on this pathogen are …

In patients that are admitted to intensive care units (ICUs), the clinical outcome of severe
infections depends on several factors, as well as the early administration of chemotherapies …

Infections associated with orthopaedic implants represent a major health concern
characterized by a remarkable incidence of morbidity and mortality. The wide variety of …