The Wilms' tumor 1 gene (WT1) has been identified as a tumor suppressor gene involved in
the etiology of Wilms' tumor. Approximately 10% of all Wilms' tumors carry mutations in the …

Wilms tumor or nephroblastoma is a pediatric kidney cancer arising from pluripotent
embryonic renal precursors. Multiple genetic loci have been linked to Wilms tumorigenesis; …

Wilms' tumor (WT) has been considered a prototype for arrested cellular differentiation in
cancer, but previous studies have relied on selected markers. We have now performed an …

The outgrowth of the ureteric bud from the posterior nephric duct epithelium and the
subsequent invasion of the bud into the metanephric mesenchyme initiate the process of …

Endometrial cancer is the most common gynaecological cancer, and is associated with
endometrial hyperplasia, unopposed oestrogen exposure and adjuvant therapy for breast …

Embryonic metanephroi, differentiating into the adult kidney, have come to be a generally
accepted model system for organogenesis. Nephrogenesis implies a highly controlled …

Wt1 is a tumour suppressor gene, mutation of which is a cause of Wilms' tumour, a childhood
renal nephroblastoma. Wt1 is expressed in a rich pattern during renal development …

During embryonic development, the anterior-posterior body axis is specified in part by the
combinatorial activities of Hox genes. Given the poor DNA binding specificity of Hox …

Wilms' Tumour I gene (WT1) is required for the correct development of the urogenital system.
To examine its regulation and expression, we created several transgenic mouse lines …

The epididymis is a tubular organ exhibiting vectorial functions of sperm concentration,
maturation, transport, and storage. The molecular basis for these functions is poorly …