Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …

Simple Summary U2 small nuclear RNA auxiliary factor 1 (U2AF1) is one of the most
important RNA splicing genes involved in regulating the alternative splicing of pre-mRNA …

Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by the selective
expansion of hematopoietic stem and progenitor cells (HSPCs) carrying somatic mutations …

Ineffective hematopoiesis is a hallmark of myelodysplastic syndromes (MDS). Hematopoietic
alterations in MDS patients strictly correlate with microenvironment dysfunctions, eventually …

The replacement of replication-coupled histones with non-canonical histone variants
provides chromatin with additional properties and contributes to the plasticity of the …

Mutations of splicing factor genes (including SF3B1, SRSF2, U2AF1 and ZRSR2) occur in
more than half of all patients with myelodysplastic syndromes (MDS), a heterogeneous …

Aims The RNA-binding protein LSM7 is essential for RNA splicing, acting as a key
component of the spliceosome complex; however, its specific role in breast cancer (BC) has …

B cell lymphopoiesis requires dynamic modulation of the B cell transcriptome for timely
coordination of somatic mutagenesis and DNA repair in progenitor B (pro-B) cells. Here, we …

RNA splicing is the process of forming mature mRNA, which is an essential phase
necessary for gene expression and controls many aspects of cell proliferation, survival, and …

Pancreatic cancer is one of the most lethal malignant tumors. However, the molecular
mechanisms responsible for its progression are little known. This study aimed to understand …