The bioavailability, transport, and bioactivity of dietary flavonoids: A review from a historical perspective

G Williamson, CD Kay, A Crozier - Comprehensive Reviews in …, 2018 - Wiley Online Library
Flavonoids are plant‐derived dietary components with a substantial impact on human
health. Research has expanded massively since it began in the 1930s, and the complex …

Targeting hypoxia-inducible factor-1, for cancer treatment: Recent advances in developing small-molecule inhibitors from natural compounds

Z Ma, X Xiang, S Li, P Xie, Q Gong, BC Goh… - Seminars in cancer …, 2022 - Elsevier
Rapid progress in molecular cancer biology coupled with the discovery of novel oncology
drugs has opened new horizons for cancer target discovery. As one of the crucial signaling …

Modulation of dysregulated cancer metabolism by plant secondary metabolites: A mechanistic review

S Fakhri, SZ Moradi, MH Farzaei, A Bishayee - Seminars in cancer biology, 2022 - Elsevier
Several signaling pathways and basic metabolites are responsible for the control of
metabolism in both normal and cancer cells. As emerging hallmarks of cancer metabolism …

Luteolin inhibited proliferation and induced apoptosis of prostate cancer cells through miR-301

K Han, W Meng, J Zhang, Y Zhou, Y Wang… - OncoTargets and …, 2016 - Taylor & Francis
Luteolin is a falvonoid compound derived from Lonicera japonica Thunb. Numerous reports
have demonstrated that luteolin has anticancer effects on many kinds of tumors. This study …

Apigenin in the regulation of cholesterol metabolism and protection of blood vessels

K Zhang, W Song, D Li, X Jin - Experimental and …, 2017 - spandidos-publications.com
Hyperlipidemia is a major independent risk factor for atherosclerosis. Seeking natural
compounds in medicinal plants capable of reducing blood fat and studying their …

MiR-34a, as a suppressor, enhance the susceptibility of gastric cancer cell to luteolin by directly targeting HK1

Y Zhou, BZ Ding, YP Lin, HB Wang - Gene, 2018 - Elsevier
Luteolin is a flavonoid compound derived from Lonicera japonica Thunb, which has been
reported to exert anticancer effects on different types of tumors. miRNAs are a kind of …

Phloridzin Docosahexaenoate, an Omega-3 Fatty Acid Ester of a Flavonoid Precursor, Inhibits Angiogenesis by Suppressing Endothelial Cell Proliferation, Migration …

W Fernando, E MacLean, S Monro, MR Power Coombs… - Biomolecules, 2024 - mdpi.com
Angiogenesis is a normal physiological process that also contributes to diabetic retinopathy-
related complications and facilitates tumor metastasis by promoting the hematogenic …

Evaluation of the possible pathways involved in the protective effects of quercetin, naringenin, and rutin at the gene, protein and miRNA levels using in-silico …

S Zargar, N Altwaijry, TA Wani, HM Alkahtani - Molecules, 2023 - mdpi.com
Flavonoids are secondary metabolites that are non-essential for plant growth or survival,
and they also provide numerous health benefits to humans. They are antioxidants that shield …

The critical role of quercetin in autophagy and apoptosis in HeLa cells

Y Wang, W Zhang, Q Lv, J Zhang, D Zhu - Tumor Biology, 2016 - Springer
In recent years, the effects of quercetin on autophagy and apoptosis of cancer cells have
been widely reported, while effects on HeLa cells are still unclear. Here, HeLa cells were …

A review on the pharmacokinetic properties of naringin and its therapeutic efficacies in respiratory diseases

X Zeng, W Su, B Liu, L Chai, R Shi… - Mini Reviews in …, 2020 - ingentaconnect.com
Flavonoids are an important class of phytopharmaceuticals in plants. Naringin (naringenin-7-
O-rhamnoglucoside) is a flavanone glycoside isolated from folk herbal medicine Exocarpium …