Malformations of the cerebral cortex are being recognized more frequently as a cause of
epilepsy, developmental delay, neurological deficits, and mental retardation. Nonetheless, a …

A diversity of animal models are available for the study of epilepsy and these models have a
proven history in advancing our understanding of basic mechanisms underlying …

Greenfield's Neuropathology, the world's leading neuropathology reference, provides a
comprehensive account of the pathological findings in neurological disease, their biological …

Focal cortical dysplasia (FCD) and glioneuronal tumors (GNT) are recognized causes of
chronic intractable epilepsy. The cellular mechanism (s) underlying their epileptogenicity …

We have recently reported a missense mutation in exon 4 of the tubulin alpha 1A (Tuba1a)
gene in a hyperactive N‐ethyl‐N‐nitrosourea (ENU) induced mouse mutant with abnormal …

Subcortical laminar heterotopia (SCLH), or 'double cortex', is a cortical dysgenesis disorder
associated with a defect in neuronal migration. Clinical manifestations are epilepsy and …

The cell-specific distribution of multidrug resistance extrusion pumps was studied in
developmental glioneuronal lesions, including focal cortical dysplasia (15 cases) and …

Object. Cerebral hemispherectomy for intractable seizures has evolved over the past 50
years, and current operations focus less on brain resection and more on disconnection. In …

The mammalian target of rapamycin (mTOR) signaling pathway regulates cell growth,
differentiation, proliferation, and metabolism. Loss‐of‐function mutations in upstream …

Objective: To determine the correlation between pre-and perioperative variables on the
outcome of children undergoing focal resections for medically intractable partial epilepsy …