In animals, the sequences for controlling gene expression do not concentrate just at the
transcription start site of genes, but are frequently thousands to millions of base pairs distal …

There is abundant variation in gene expression between individuals, populations, and
species. The evolution of gene regulation and expression within and between species is …

A long-standing question in gene regulation is how remote enhancers communicate with
their target promoters, and specifically how chromatin topology dynamically relates to gene …

Previous studies have identified topologically associating domains (TADs) as basic units of
genome organization. We present evidence of a previously unreported level of genome …

The prevailing view of metazoan gene regulation is that transcription is facilitated through
the formation of static activator complexes at distal regulatory regions. Here, we employed …

Genomes 5 has been completely revised and updated. It is a thoroughly modern textbook
about genomes and how they are investigated. As with previous Genomes editions …

Chromosomes in the eukaryotic nucleus are highly compacted. However, for many
functional processes, including transcription initiation, the pairwise motion of distal …

How remote enhancers interact with appropriate target genes persists as a central mystery
in gene regulation. Here, we exploit the properties of transvection to explore enhancer …

It is now widely appreciated that the spatial organization of the genome is nonrandom, and
its complex 3D folding has important consequences for many genome processes. Recent …

Abstract Interleukin-2 (IL-2)-deficient mice have cytoarchitectural hippocampal modifications
and impaired learning and memory ability reminiscent of Alzheimer's disease. IL-2 …