The routine and often unavoidable exposure to solar ultraviolet (UV) radiation makes it one of the most significant environmental DNA-damaging agents to which humans are exposed …
I Martic, P Jansen-Dürr, M Cavinato - Cells, 2022 - mdpi.com
The human skin is exposed daily to different environmental factors such as air pollutants and ultraviolet (UV) light. Air pollution is considered a harmful environmental risk to human skin …
Abstract The Free Radical Theory of Ageing, was first proposed by Denham Harman in the mid-1950's, based largely on work conducted by Rebeca Gerschman and Daniel Gilbert. At …
M Cavinato, B Waltenberger, G Baraldo, CVC Grade… - Biogerontology, 2017 - Springer
Skin is continuously exposed to a variety of environmental stresses, including ultraviolet (UV) radiation. UVB is an inherent component of sunlight that crosses the epidermis and …
M Cavinato, P Jansen-Dürr - Experimental gerontology, 2017 - Elsevier
Due to its ability to cross the epidermis and reach the upper dermis where it causes cumulative DNA damage and increased oxidative stress, UVB is considered the most …
J Zhang, H Yu, MQ Man, L Hu - Aging Cell, 2024 - Wiley Online Library
Skin aging is characterized by changes in its structural, cellular, and molecular components in both the epidermis and dermis. Dermal aging is distinguished by reduced dermal …
The aging process starts directly after birth and lasts for the entire lifespan; it manifests itself with a decline in an organism's ability to adapt and is linked to the development of age …
J Ma, Y Teng, Y Huang, X Tao, Y Fan - Frontiers in Pharmacology, 2022 - frontiersin.org
Photoaging is characterized by a chronic inflammatory response to UV light. One of the most prominent features of cutaneous photoaging is wrinkling, which is due primarily to a loss of …
M Wang, P Charareh, X Lei… - Oxidative Medicine and …, 2019 - Wiley Online Library
Autophagy is an essential cellular process that maintains balanced cell life. Restriction in autophagy may induce degenerative changes in humans. Natural or pathological aging of …