The development of high-throughput RNA structure profiling methods in the past decade has
greatly facilitated our ability to map and characterize different aspects of RNA structures …

Lentiviral vectors (LVs) are potent tools for the delivery of genes of interest into mammalian
cells and are now commonly utilised within the growing field of cell and gene therapy for the …

Lentiviral vectors (LV) have seen considerably increase in use as gene therapy vectors for
the treatment of acquired and inherited diseases. This review presents the state of the art of …

After initiating antiretroviral therapy (ART), a rapid decline in HIV viral load is followed by a
long period of undetectable viremia. Viral outgrowth assay suggests the reservoir continues …

Many microbial populations rapidly adapt to changing environments with multiple variants
competing for survival. To quantify such complex evolutionary dynamics in vivo, time …

Non-coding RNAs are ubiquitous, but the discovery of new RNA gene sequences far
outpaces the research on the structure and functional interactions of these RNA gene …

Chimeric antigen receptor (CAR) T cell therapy, in which a patient's own T lymphocytes are
engineered to recognize and kill cancer cells, has achieved remarkable success in some …

Different mechanisms mediate the toxicity of RNA. Genomic retroviral mRNA hijacks infected
host cell factors to enable virus replication. The viral genomic RNA of the human …

Nucleocytoplasmic distribution of Yap/TAZ is regulated by the Hippo pathway and the
cytoskeleton. While interactions with cytosolic and nuclear “retention factors”(14–3–3 and …

HIV is notorious for its capacity to evade immunity and anti-viral drugs through rapid
sequence evolution. Knowledge of the functional effects of mutations to HIV is critical for …