The ubiquitous family of AP-1 dimeric transcription complexes is involved in virtually all
cellular and physiological functions. It is paramount for cells to reprogram gene expression …

Chemical reprogramming offers an unprecedented opportunity to control somatic cell fate
and generate desired cell types including pluripotent stem cells for applications in …

We recently demonstrated the chemical reprogramming of human somatic cells to
pluripotent stem cells (hCiPSCs), which provides a robust approach for cell fate …

Pluripotent stem cells hold great promise in regenerative medicine and developmental
biology studies. Mitochondrial metabolites, including tricarboxylic acid (TCA) cycle …

Transposable elements (TEs) make up a majority of a typical eukaryote's genome, and
contribute to cell heterogeneity in unclear ways. Single-cell sequencing technologies are …

Cellular reprogramming by only small molecules holds enormous potentials for regenerative
medicine. However, chemical reprogramming remains a slow process and labour intensive …

Chemical reprogramming provides a powerful platform for exploring the molecular dynamics
that lead to pluripotency. Although previous studies have uncovered an intermediate …

In mammals, many organs lack robust regenerative abilities. Lost cells in impaired tissue
could potentially be compensated by converting nearby cells in situ through in vivo …

Articular cartilage damage is a universal health problem. Despite recent progress,
chondrocyte dedifferentiation has severely compromised the clinical outcomes of cell-based …

Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs), which is a
highly heterogeneous process. Here we report the cell fate continuum during somatic cell …