Therapeutic potential of quercetin: new insights and perspectives for human health

B Salehi, L Machin, L Monzote, J Sharifi-Rad… - ACS …, 2020 - ACS Publications
Quercetin (Que) and its derivatives are naturally occurring phytochemicals with promising
bioactive effects. The antidiabetic, anti-inflammatory, antioxidant, antimicrobial, anti …

Neuropharmacological effects of quercetin: a literature-based review

MS Islam, C Quispe, R Hossain, MT Islam… - Frontiers in …, 2021 - frontiersin.org
Quercetin (QUR) is a natural bioactive flavonoid that has been lately very studied for its
beneficial properties in many pathologies. Its neuroprotective effects have been …

Regulatory effects of quercetin on M1/M2 macrophage polarization and oxidative/antioxidative balance

CF Tsai, GW Chen, YC Chen, CK Shen, DY Lu… - Nutrients, 2021 - mdpi.com
Macrophage polarization plays essential and diverse roles in most diseases, such as
atherosclerosis, adipose tissue inflammation, and insulin resistance. Homeostasis …

Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease

E Zaplatic, M Bule, SZA Shah, MS Uddin, K Niaz - Life sciences, 2019 - Elsevier
Quercetin belongs to the flavonoids family, which is present in most of the plants including
fruits, vegetables, green tea and even in red wine having antioxidant activities. It is available …

Apolipoprotein E, receptors, and modulation of Alzheimer's disease

N Zhao, CC Liu, W Qiao, G Bu - Biological psychiatry, 2018 - Elsevier
Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous
systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to …

Natural compounds for Alzheimer's disease therapy: a systematic review of preclinical and clinical studies

S Andrade, MJ Ramalho, JA Loureiro… - International journal of …, 2019 - mdpi.com
Alzheimer's Disease (AD) is a neurodegenerative disorder related with the increase of age
and it is the main cause of dementia in the world. AD affects cognitive functions, such as …

Quercetin is an active agent in berries against neurodegenerative diseases progression through modulation of Nrf2/HO1

AB Bayazid, BO Lim - Nutrients, 2022 - mdpi.com
Berries are well-known fruits for their antioxidant effects due to their high content of
flavonoids, and quercetin is one of the potent bioactive flavonoids. Although oxidative stress …

Bioactive polyphenols and neuromodulation: molecular mechanisms in neurodegeneration

F Di Meo, A Valentino, O Petillo, G Peluso… - International journal of …, 2020 - mdpi.com
The interest in dietary polyphenols in recent years has greatly increased due to their
antioxidant bioactivity with preventive properties against chronic diseases. Polyphenols, by …

Quercetin Attenuates Diabetic Peripheral Neuropathy by Correcting Mitochondrial Abnormality via Activation of AMPK/PGC-1α Pathway in vivo and in vitro

Q Zhang, W Song, B Zhao, J Xie, Q Sun, X Shi… - Frontiers in …, 2021 - frontiersin.org
The AMPK/PGC-1α pathway-mediated mitochondrial dysfunction has been supposed to
play a crucial role in pathogenesis of diabetic peripheral neuropathy (DPN). The present …

Lifelong absence of microglia alters hippocampal glutamatergic networks but not synapse and spine density

M Surala, L Soso-Zdravkovic, D Munro, A Rifat… - EMBO …, 2024 - embopress.org
Microglia sculpt developing neural circuits by eliminating excess synapses in a process
called synaptic pruning, by removing apoptotic neurons, and by promoting neuronal …