The study of chronic pain continues to generate ever-increasing numbers of publications,
but safe and efficacious treatments for chronic pain remain elusive. Recognition of sex …

Spinal cord injury (SCI) is a devastating condition that causes severe loss of motor, sensory
and autonomic functions. Additionally, many individuals experience chronic neuropathic …

The development and maintenance of chronic neuropathic pain involves distorted neuroglial
interactions, which result in prolonged perturbations of immune and inflammatory response …

Previous studies on the mechanisms of peripheral nerve injury (PNI) have mainly focused
on the pathophysiological changes within a single injury site. However, recent studies have …

Abstract Purpose of Review The purpose of the present systematic review is to provide a
current understanding of the mechanism of action and the evidence available to support …

Despite the overwhelming female-predominance in chronic pain disorders, preclinical pain
studies have historically excluded females as research subjects. Male-biased explanations …

While numerous studies and patient experiences have demonstrated the efficacy of spinal
cord stimulation as a treatment for chronic neuropathic pain, the exact mechanism …

Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting painful neuropathy
that occurs commonly during cancer management, which often leads to the discontinuation …

While embryonic mammalian central nervous system (CNS) axons readily grow and
differentiate, only a minority of fully differentiated mature CNS neurons are able to …

Spinal cord stimulation (SCS) is a last resort treatment for pain relief in painful diabetic
peripheral neuropathy (PDPN) patients. However, the effectivity of SCS in PDPN is limited …