The role of mitochondrial reactive oxygen species in insulin resistance
Insulin resistance is one of the earliest pathological features of a suite of diseases including
type 2 diabetes collectively referred to as metabolic syndrome. There is a growing body of …
type 2 diabetes collectively referred to as metabolic syndrome. There is a growing body of …
The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation
Background RNA-binding proteins (RBPs) function as master regulators of gene expression.
Alterations in RBP expression and function are often observed in cancer and influence …
Alterations in RBP expression and function are often observed in cancer and influence …
Targeting prostate tumor low–molecular weight tyrosine phosphatase for oxidation-sensitizing therapy
SM Stanford, TP Nguyen, J Chang, Z Zhao… - Science …, 2024 - science.org
Protein tyrosine phosphatases (PTPs) play major roles in cancer and are emerging as
therapeutic targets. Recent reports suggest low–molecular weight PTP (LMPTP)—encoded …
therapeutic targets. Recent reports suggest low–molecular weight PTP (LMPTP)—encoded …
SLC25A51 decouples the mitochondrial NAD+/NADH ratio to control proliferation of AML cells
SLC25A51 selectively imports oxidized NAD+ into the mitochondrial matrix and is required
for sustaining cell respiration. We observed elevated expression of SLC25A51 that …
for sustaining cell respiration. We observed elevated expression of SLC25A51 that …
[HTML][HTML] A sensitive mass spectrometric assay for mitochondrial CoQ pool redox state in vivo
N Burger, A Logan, TA Prime, A Mottahedin… - Free Radical Biology …, 2020 - Elsevier
Coenzyme Q (CoQ) is an essential cofactor, primarily found in the mitochondrial inner
membrane where it functions as an electron carrier in the respiratory chain, and as a …
membrane where it functions as an electron carrier in the respiratory chain, and as a …
Novel strategy for untargeted chiral metabolomics using liquid chromatography-high resolution tandem mass spectrometry
Stereospecific recognition of metabolites plays a significant role in the detection of potential
disease biomarkers thereby providing new insights in diagnosis and prognosis. d …
disease biomarkers thereby providing new insights in diagnosis and prognosis. d …
Mass spectrometry-based determination of lipids and small molecules composing adipose tissue with a focus on brown adipose tissue
Adipose tissue has been the subject of research for a very long time. Many studies perform a
comprehensive analysis of different types of adipose tissue with an emphasis on brown …
comprehensive analysis of different types of adipose tissue with an emphasis on brown …
Formation of I2+ III2 supercomplex rescues respiratory chain defects
C Liang, A Padavannil, S Zhang, S Beh, DRL Robinson… - Cell Metabolism, 2025 - cell.com
Mitochondrial electron transport chain (ETC) complexes partition between free complexes
and quaternary assemblies known as supercomplexes (SCs). However, the physiological …
and quaternary assemblies known as supercomplexes (SCs). However, the physiological …
Enriched pathways of calcium regulation, cellular/oxidative stress, inflammation, and cell proliferation characterize gluteal muscle of standardbred horses between …
SJ Valberg, D Velez-Irizarry, ZJ Williams, ML Henry… - Genes, 2022 - mdpi.com
Certain Standardbred racehorses develop recurrent exertional rhabdomyolysis (RER-STD)
for unknown reasons. We compared gluteal muscle histopathology and gene/protein …
for unknown reasons. We compared gluteal muscle histopathology and gene/protein …
Metabolomics-based phenotypic screens for evaluation of drug synergy via direct-infusion mass spectrometry
Drugs used in combination can synergize to increase efficacy, decrease toxicity, and prevent
drug resistance. While conventional high-throughput screens that rely on univariate data are …
drug resistance. While conventional high-throughput screens that rely on univariate data are …