Organoids are tiny, self-organized, three-dimensional tissue cultures that are derived from
the differentiation of stem cells. The growing interest in the use of organoids arises from their …

Cardiovascular aging presents a formidable challenge, as the aging process can lead to
reduced cardiac function and heightened susceptibility to cardiovascular diseases …

Cardiovascular diseases (CVD) are predominantly an aging disease. Important sex-specific
differences exist and the mechanism (s) by which this sex-by-age interaction influences CVD …

Atherosclerosis-related coronary artery disease (CAD) is the leading cause of mortality and
morbidity worldwide. This requires effective primary and secondary prevention in reducing …

Atherosclerosis-related coronary artery disease (CAD) is one of the leading sources of
mortality and morbidity in the world. Primary and secondary prevention appear crucial to …

Abnormal activation of protein kinases and phosphatases is implicated in various
tumorigenesis, including hepatocellular carcinoma (HCC). Advanced HCC patients are …

Over the years strong evidence has been accumulated showing that aerobic physical
exercise exerts beneficial effects on the prevention and reduction of cardiovascular risk …

Statins inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, and
are the cornerstone of lipid-lowering treatment. They significantly reduce cardiovascular …

Cardiomyopathy is a common complication in diabetic patients. Ventricular dysfunction
without coronary atherosclerosis and hypertension is driven by hyperglycemia …

The outer layer of endothelial cells (ECs), consisting of the endothelial glycocalyx (eGC) and
the cortex (CTX), provides a protective barrier against vascular diseases. Structural and …