Cytotoxic lymphocytes rapidly respond and destroy both malignant cells and cells infected
with intracellular pathogens. One mechanism, known as granule exocytosis, employs the …

Although proteolysis mediated by granzymes has an important role in the immune response
to infection or tumours, unrestrained granzyme activity may damage normal cells. In this …

In recent years, procedures for selecting the N-terminal peptides of proteins with analysis by
mass spectrometry have been established to characterize protease-mediated cleavage and …

After recognition of cognate antigen (Ag), effector CD8+ T cells secrete serine proteases
called granzymes in conjunction with perforin, allowing granzymes to enter and kill target …

Granzymes are serine proteases mainly found in cytotoxic lymphocytes. The most-studied
member of this group is granzyme B, which is a potent cytotoxin that has set the paradigm …

The review discusses the controversies in the field of cytotoxic lymphocyte secretory granule
death pathways. A pore-forming protein, PRF, and serine proteases, Grz, are key effector …

Cytotoxic lymphocytes are armed with granules that are released in the granule‐exocytosis
pathway to kill tumor cells and virus‐infected cells. Cytotoxic granules contain the pore …

Granzymes (Grz) are a family of serine proteases found in the granules of cytotoxic
lymphocytes and are emerging as an important group of proteins involved in immune …

The iceLogo web server and SOAP service implement the previously published iceLogo
algorithm. iceLogo builds on probability theory to visualize protein consensus sequences in …

Proteolytic cleavage is a ubiquitous, irreversible, posttranslational modification that changes
protein structure and function and plays an important role in numerous physiological and …