Pulmonary hypertension is defined as a resting mean pulmonary artery pressure of 25 mm
Hg or above. This review deals with pulmonary arterial hypertension (PAH), a type of …

Transforming growth factor β (TGF-β) family members signal via heterotetrameric complexes
of type I and type II dual specificity kinase receptors. The activation and stability of the …

Expansion on stiff culture substrates activates pro-fibrotic cell programs that are retained by
mechanical memory. Here, we show that priming on physiologically soft silicone substrates …

Bone morphogenetic proteins (BMPs) are secreted extracellular matrix (ECM)-associated
proteins that regulate a wide range of developmental processes, including limb and kidney …

Major discoveries have been obtained within the last decade in the field of hereditary
predisposition to pulmonary arterial hypertension (PAH). Among them, the identification of …

The cardiovascular research and clinical communities are ideally positioned to address the
epidemic of noncommunicable causes of death, as well as advance our understanding of …

Abstract Aims Extracellular vesicles (EVs) from mice with monocrotaline (MCT)-induced
pulmonary hypertension (PH) induce PH in healthy mice, and the exosomes (EXO) fraction …

Pulmonary hypertension (PH) is a deadly vascular disease with enigmatic molecular origins.
We found that vascular extracellular matrix (ECM) remodeling and stiffening are early and …

Hypoxia, or low oxygen tension, is a unique environmental stress that induces global
changes in a complex regulatory network of transcription factors and signaling proteins to …

Development of the vascular disease pulmonary hypertension (PH) involves disparate
molecular pathways that span multiple cell types. MicroRNAs (miRNAs) may coordinately …