Biologic Therapies for Severe Asthma Patients with severe asthma are at increased risk for a
decreased quality of life, fixed airway obstruction, hospitalization, and death. Biologics may …

There has been a steep increase in allergic and autoimmune diseases, reaching epidemic
proportions and now affecting more than one billion people worldwide. These diseases are …

Objective To provide evidence‐based recommendations and expert guidance for the
management of antineutrophil cytoplasmic antibody–associated vasculitis (AAV), including …

Thrombosis is the most feared complication of cardiovascular diseases and a main cause of
death worldwide, making it a major health-care challenge. Platelets and the coagulation …

Abstract Background Monoclonal antibodies targeting IgE, interleukin-4 and-13, and
interleukin-5 are effective in treating severe type 2 asthma, but new targets are needed …

Background Chronic rhinosinusitis with nasal polyps affects approximately 2–4% of the
general population, and long-term use of systemic corticosteroids is associated with adverse …

Asthma is a heterogeneous lung disease with variable phenotypes (clinical presentations)
and distinctive endotypes (mechanisms). Over the last decade, considerable efforts have …

Eosinophils play a homeostatic role in the body's immune responses. These cells are
involved in combating some parasitic, bacterial, and viral infections and certain cancers and …

Asthma is a chronic inflammatory airway disease resulting in airflow obstruction, which in
part can become irreversible to conventional therapies, defining the concept of airway …

Blood cells play essential roles in human health, underpinning physiological processes
such as immunity, oxygen transport, and clotting, which when perturbed cause a significant …