Annotating protein sequences according to their biological functions is one of the key steps
in understanding microbial diversity, metabolic potentials, and evolutionary histories …

DNA supercoiling is central to many fundamental processes of living organisms. Its average
level along the chromosome and over time reflects the dynamic equilibrium of opposite …

The interaction between a pathogen and a host is a highly dynamic process in which both
agents activate complex programs. Here, we introduce a single-cell RNA-sequencing …

DNA supercoiling acts as a global transcriptional regulator in bacteria, that plays an
important role in adapting their expression programme to environmental changes, but for …

In bacteria functionally related genes comprising metabolic pathways and protein
complexes are frequently encoded in operons and are widely conserved across …

Here, we determined the relative importance of different transcriptional mechanisms in the
genome-reduced bacterium Mycoplasma pneumoniae, by employing an array of …

Gene context can have significant impact on gene expression but is currently not integrated
in quantitative models of gene regulation despite known biophysical principles and …

DNA supercoiling acts as a global and ancestral regulator of bacterial gene expression. In
this review, we advocate that it plays a pivotal role in host-pathogen interactions by …

Gene duplication followed by mutation is a classic mechanism of neofunctionalization,
producing gene families with functional diversity. In some cases, a single point mutation is …

Gene expression levels are influenced by multiple coexisting molecular mechanisms. Some
of these interactions such as those of transcription factors and promoters have been studied …