Hydrogen bonding network-enabled Brønsted acid-catalyzed Friedel–Crafts reactions: a green approach to access unsymmetrical diaryl-and triarylmethanes

S Singh, S Mondal, N Vodnala, CK Hazra - Green Chemistry, 2023 - pubs.rsc.org
Unsymmetrical di-and triarylmethanes are generally synthesized through metal-catalyzed
cross-coupling or Friedel–Crafts arylation using multistep harsh reaction conditions with pre …

Alternative Reactions to Friedel-crafts Acylation on Highly Activated Substrates

DI Leite, LCF Pimentel, MCA Dias… - Current Organic …, 2024 - benthamdirect.com
Friedel-crafts acylation (FCAcyl) is the most widespread method used to prepare aryl
ketones and aldehydes. However, depending on the type of group attached to the benzene …

Lewis Acid-Promoted Typical Friedel–Crafts Reactions Using DMSO as a Carbon Source

N Vodnala, S Singh, CK Hazra - The Journal of Organic Chemistry, 2022 - ACS Publications
This study reports a mild and efficient synthetic protocol for the synthesis of symmetrical and
unsymmetrical diarylmethanes (DAMs). Using DMSO as the C1 source and TMSOTf as the …

Sustainable Sulfonic Acid Functionalized Tubular Shape Mesoporous Silica as a Heterogeneous Catalyst for Selective Unsymmetrical Friedel–Crafts Alkylation in One …

S Singh, A Kumar, L Nebhani, CK Hazra - JACS Au, 2023 - ACS Publications
The development of general and more sustainable heterogeneous catalytic processes for
Friedel–Crafts (FC) alkylation reactions is a key objective of interest for the synthesis of …

Brønsted Acid-Mediated Multicomponent One-Pot Approach to Direct Construction of 4-Aryl-hydrocoumarin Derivatives

P Sharma, S Singh, CK Hazra - The Journal of Organic Chemistry, 2023 - ACS Publications
The facile and efficient synthesis of a unique class of 4-aryl-hydrocoumarins having
enormous applications in medicinal chemistry and natural products is presented. We have …

Silyl Cation-Initiated, Brønsted Acid-Catalyzed Strategy toward Unsymmetrical 3, 3-Disubstituted 2-Oxindoles and Azonazine Cores

J Khan, N Yadav, A Tyagi, CK Hazra - The Journal of Organic …, 2022 - ACS Publications
Herein, a mild, metal-free, robust approach for synthesizing valuable and sterically
demanding unsymmetrical 3, 3-disubstituted 2-oxindoles via reductive cyclization of α …

Brønsted Acid-Catalyzed Synthesis of 4-Functionalized Tetrahydrocarbazol-1-ones from 1, 4-Dicarbonylindole Derivatives

S Gómez-Gil, M Solas, S Suárez-Pantiga… - The Journal of Organic …, 2023 - ACS Publications
A p-toluenesulfonic acid-catalyzed cascade reaction is reported for the synthesis of 4-
functionalized tetrahydrocarbazolones via the reaction of 4-(indol-2-yl)-4-oxobutanal …

A Regioselective, One-Pot, Transition-Metal-Free α-Alkylation of Quinone Monoacetals for Various Organic Transformations

P Sharma, R Vishwakarma, R Rakheja… - Organic …, 2024 - ACS Publications
Regioselective reactions of biologically significant quinones are challenging. An
unprecedented advancement in quinone monoacetal (QMA) chemistry is proposed for …

One-Pot Sequential Synthesis of 3, 3′-or 2, 3′-Bis (indolyl) methanes by Using 1, 3-Dithiane as the Methylene Source

K Dong, J Li, RP Li, M Mao, J Liu… - The Journal of Organic …, 2022 - ACS Publications
A simple and efficient method for structurally diverse symmetrical and unsymmetrical 3, 3′-
and 2, 3′-bisindolylmethanes has been developed through a one-pot sequential reaction …

Porous Cross-Linked Polymer PPBI@ Mn Catalyzed the Selective Synthesis of Bisindolylmethane Derivatives

K Zhang, H Zhu, D Wang, ZC Duan - Catalysis Letters, 2024 - Springer
The quest for highly active and efficient ligands in coordination polymer-based catalytic
applications is paramount. The new porous cross-linked polymer manganese composites …