Histology and immunohistochemistry of thin tissue sections have been the standard
diagnostic procedure in many diseases for decades. This method is highly specific for …

Microscopic X-ray computed tomography (microCT) is a structural ex vivo imaging technique
providing genuine isotropic 3D images from biological samples at micron resolution …

To quantitatively evaluate brain tissue and its corresponding function, knowledge of the 3D
cellular distribution is essential. The gold standard to obtain this information is histology, a …

Organismal phenotypes frequently involve multiple organ systems. Histology is a powerful
way to detect cellular and tissue phenotypes, but is largely descriptive and subjective. To …

High-contrast, high-resolution imaging of biomedical specimens is indispensable for
studying organ function and pathologies. Conventional histology, the gold standard for soft …

Purpose The goal of breast cancer surgery is to remove all of the cancer with a minimum of
normal tissue, but absence of full 3-dimensional information on the specimen makes this …

A multiscale three-dimensional (3D) virtual histology approach is presented, based on two
configurations of propagation phase-contrast X-ray tomography, which have been …

Background: Micrometer-resolution neuroimaging with gold-standard conventional histology
requires tissue fixation and embedding. The exchange of solvents for the creation of …

We present a three-dimensional (3D) approach for virtual histology and histopathology
based on multi-scale phase contrast x-ray tomography, and use this to investigate the …

In this study, we use synchrotron-based multi-modal X-ray tomography to examine human
cerebellar tissue in three dimensions at two levels of spatial resolution (2.3 µm and 11.9 …