Sialidases, or neuraminidases, are enzymes that catalyze the hydrolysis of sialic acid (Sia)-
containing molecules, mostly removal of the terminal Sia (desialylation). By desialylation …

Conspectus Sialic acids are fascinating negatively charged nine-carbon monosaccharides.
Sialic acid-containing glycans and glycoconjugates are structurally diverse, functionally …

Fluorinated carbohydrates have found many applications in the glycosciences. Typically,
these contain fluorination at a single position. There are not many applications involving …

Sialidases (SAs) and sialyltransferases (STs), the enzymes responsible for removing and
adding sialic acid to other glycans, play essential roles in viruses, bacteria, parasites, and …

Influenza virus is the main cause of an infectious disease called influenza affecting the
respiratory system including the throat, nose and lungs. Neuraminidase inhibitors are …

Elevated bacterial sialidase activity in the female genital tract is strongly associated with
poor health outcomes including preterm birth and bacterial vaginosis (BV). These negative …

In nature, almost all cells are covered with a complex array of glycan chain namely sialic
acids or nuraminic acids, a negatively charged nine carbon sugars which is considered for …

Bacterial sialidases (SA) are validated drug targets expressed by common human
pathogens such as Streptococcus pneumoniae, Vibrio cholerae, or Clostridium perfringens …

The reaction of methyl ester C-11, C-15 bis-TBDPS derivative of cloprostenol with DAST in
CH 2 Cl 2 at− 78° C followed by warming to room temperature results in a product of SN 2 …

Sialic acids, a negatively charged nine-carbon saccharide unit, are key components of cell-
surface glycans and are found predominantly at the terminal end of the lipid bilayer and thus …