Individuals with spinal cord injury (SCI) can face decades with permanent disabilities.
Advances in clinical management have decreased morbidity and improved outcomes, but …

Spinal cord injury (SCI) lesions present diverse challenges for repair strategies.
Anatomically complete injuries require restoration of neural connectivity across lesions …

Transected axons fail to regrow in the mature central nervous system. Astrocytic scars are
widely regarded as causal in this failure. Here, using three genetically targeted loss-of …

Transcellular propagation of protein aggregate" seeds" has been proposed to mediate the
progression of neurodegenerative diseases in tauopathies and α-synucleinopathies. We …

Synapses are fundamental units of communication in the brain. The prototypical synapse-
organizing complex neurexin-neuroligin mediates synapse development and function and is …

Background The extracellular matrix (ECM) of the brain is rich in glycosaminoglycans such
as chondroitin sulfate (CS) and hyaluronan. These glycosaminoglycans are organized into …

There are numerous mechanisms by which glioblastoma cells evade immunological
detection, underscoring the need for strategic combinatorial treatments to achieve …

Tauopathies are a group of neurodegenerative diseases characterized by the progressive
accumulation across the brain of hyperphosphorylated aggregates of the microtubule …

Heparan sulfate is a ubiquitous, variably sulfated interactive glycosaminoglycan that
consists of repeating disaccharides of glucuronic acid and glucosamine that are subject to a …

ABSTRACT In 2014, enterovirus D68 (EV-D68) emerged causing outbreaks of severe
respiratory disease in children worldwide. In a subset of patients, EV-D68 infection was …