Recurrent endometrial cancer: local and systemic treatment options

H Rütten, C Verhoef, WJ van Weelden, A Smits… - Cancers, 2021 - mdpi.com
Simple Summary In this review, we discuss the different treatment strategies in recurrent
endometrial cancer. The incidence of endometrial cancer is rising. The available treatment …

The prognostic value of MEK pathway–associated estrogen receptor signaling activity for female cancers

CW Ng, YTM Tsang, DM Gershenson… - British journal of …, 2024 - nature.com
Background Other than for breast cancer, endocrine therapy has not been highly effective for
gynecologic cancers. Endocrine therapy resistance in estrogen receptor positive …

Relevance of molecular profiling in patients with low-grade endometrial cancer

SW Vrede, J Kasius, J Bulten, S Teerenstra… - JAMA network …, 2022 - jamanetwork.com
Importance Patients with low-grade (ie, grade 1-2) endometrial cancer (EC) are
characterized by their favorable prognosis compared with patients with high-grade (ie, grade …

Functional estrogen receptor signal transduction pathway activity and antihormonal therapy response in low‐grade ovarian carcinoma

CSE Hendrikse, P van der Ploeg, NMA van de Kruis… - Cancer, 2023 - Wiley Online Library
Background Advanced low‐grade ovarian carcinoma (LGOC) is difficult to treat. In several
studies, high estrogen receptor (ER) protein expression was observed in patients with …

RNA based approaches to profile oncogenic pathways from low quantity samples to drive precision oncology strategies

A Van De Stolpe, W Verhaegh, JY Blay, CX Ma… - Frontiers in …, 2021 - frontiersin.org
Precision treatment of cancer requires knowledge on active tumor driving signal
transduction pathways to select the optimal effective targeted treatment. Currently only a …

Predictive and prognostic biomarker identification in a large cohort of androgen receptor-positive salivary duct carcinoma patients scheduled for combined androgen …

G Lassche, Y Tada, CML Van Herpen, MA Jonker… - Cancers, 2021 - mdpi.com
Simple Summary Androgen receptor signaling seems pivotal in aggressive salivary duct
carcinoma. However, androgen deprivation therapy (ADT) frequently fails, emphasizing the …

Estrogen/progesterone receptor loss, CTNNB1 and KRAS mutations are associated with local recurrence or distant metastasis in low-grade endometrial endometrioid …

R Chibbar, S Foerstner, J Suresh… - Applied …, 2023 - journals.lww.com
A subset of endometrial endometrioid carcinomas (EECs) with low-grade histology recur
with poor outcomes. Published evidence suggests that poor outcomes may be associated …

[HTML][HTML] Identification of novel key genes associated with uterine corpus endometrial carcinoma progression and prognosis

H Li, Q Zhou, Z Wu, X Lu - Annals of Translational Medicine, 2023 - ncbi.nlm.nih.gov
Background Uterine corpus endometrial carcinoma (UCEC) is a common malignant cancer
type which affects the health of women worldwide. However, its molecular mechanism has …

The effect of progestin therapy in advanced and recurrent endometrial cancer: A systematic review and meta‐analysis

WJ Van Weelden, PB Birkendahl… - … Journal of Obstetrics …, 2023 - Wiley Online Library
Background Fifteen percent of patients with endometrial cancer (EC) have advanced stage
disease or develop a recurrence. Progestins have been applied as systemic treatment for …

Estradiol mediates the interaction of LINC01541 and miR-429 to promote angiogenesis of G1/G2 endometrioid adenocarcinoma in-vitro: A pilot study

D Qiao, X Qin, H Yang, X Liu, L Liu, S Liu… - Frontiers in Oncology, 2022 - frontiersin.org
Background Endometrioid adenocarcinoma (EAC) is the most common subtype of
endometrial cancer (EC) and is an estrogen-related cancer. In this study, we sought to …