Klotho is a critical protein that protects the kidney. Klotho is severely downregulated in
chronic kidney disease (CKD), and its deficiency is implicated in the pathogenesis and …

Proteolysis-targeting chimera (PROTAC) and other targeted protein degradation (TPD)
molecules that induce degradation by the ubiquitin-proteasome system (UPS) offer new …

Background Tripartite motif (TRIM) family proteins have more than 80 members and are
widely found in various eukaryotic cells. Most TRIM family proteins participate in the …

Oxaliplatin is a widely used chemotherapy drug for patients with advanced colorectal cancer
(CRC); however, frequent drug resistance limits its therapeutic efficacy in patients. Here, this …

Background Degrons are short linear motifs, bound by E3 ubiquitin ligase to target protein
substrates to be degraded by the ubiquitin-proteasome system. Mutations leading to …

How the KRAS oncogene drives cancer growth remains poorly understood. Therefore, we
established a systemwide portrait of KRAS-and extracellular signal–regulated kinase (ERK) …

Tumor suppression by inducing NCOA4-mediated ferroptosis has been shown to be feasible
in a variety of tumors, including gliomas. However, the regulatory mechanism of ferroptosis …

Abstract Background Nuclear Yes1‐associated transcriptional regulator (YAP1) promotes
tumor progression. However, the function of cytoplasmic YAP1 in breast cancer cells and its …

The tripartite motif (TRIM) protein family has been investigated in multiple human cancers,
including gastric cancer (GC). However, the role of TRIM69 in the anoikis resistance and …

As an important post-translational modification, lysine ubiquitination participates in
numerous biological processes and is involved in human diseases, whereas the site …