The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …

Little is known about extracellular matrix (ECM) contributions to formation of the earliest cell
lineages in the embryo. Here, we show that the proteoglycan versican and …

The extracellular matrix (ECM) plays an important role in numerous processes including
cellular proliferation, differentiation, migration, maturation, adhesion guidance and axonal …

VCAN-related vitreoretinopathy, which includes Wagner syndrome and erosive
vitreoretinopathy (ERVR), is characterized by" optically empty vitreous" on slit-lamp …

Background Wagner vitreoretinopathy (WVR) is a rare autosomal dominant vitreoretinopathy
caused by pathogenic variants in the VCAN gene. The aim of this study was to report a novel …

Wagner disease is a rare nonsyndromic autosomal‐dominant vitreoretinopathy, associated
with splice mutations specifically targeting VCAN exon 8. We report the extensive genetic …

Purpose To report the clinical and molecular findings of a kindred with Wagner syndrome
(WS) revealed by intraocular inflammatory features. Methods Eight available family …

Purpose To evaluate the spectrum of morphologic abnormalities in patients with Wagner
syndrome by spectral-domain optical coherence tomography (SD OCT). Design …

Background Wagner vitreoretinopathy (WVR) is a rare non-syndromic autosomal dominant
inherited vitreoretinopathy. We studied the phenotypes of two Chinese families with WVR …

Purpose Wagner syndrome is an autosomal genetic vitreoretinopathy characterized by
chorioretinal atrophy, avascular vitreous veils, reduced visual acuity and early retinal …