Leishmaniasis is regarded as a neglected tropical disease by World Health Organization (WHO) and is ranked next to malaria as the deadliest protozoan disease. The primary …
AC Pinheiro, MVN de Souza - RSC Medicinal Chemistry, 2022 - pubs.rsc.org
Leishmaniasis is a complex protozoan infectious disease and, associated with malnutrition, poor health services and unavailability of prophylactic control measures, neglected …
DA Winkler - Frontiers in Chemistry, 2021 - frontiersin.org
Neglected tropical diseases continue to create high levels of morbidity and mortality in a sizeable fraction of the world's population, despite ongoing research into new treatments …
ALS Santos, LA Braga-Silva, DS Gonçalves, LS Ramos… - Journal of Fungi, 2021 - mdpi.com
The repurposing strategy was applied herein to evaluate the effects of lopinavir, an aspartic protease inhibitor currently used in the treatment of HIV-infected individuals, on the globally …
S Jain, U Sahu, A Kumar, P Khare - Pharmaceutics, 2022 - mdpi.com
Leishmaniasis is a tropical disease caused by a protozoan parasite Leishmania that is transmitted via infected female sandflies. At present, leishmaniasis treatment mainly counts …
The recent outlook of leishmaniasis as a global public health concern coupled with the reportage of resistance and lack of efficacy of most antileishmanial drugs calls for a …
H Berhe, M Kumar Cinthakunta Sridhar, M Zerihun… - Pharmaceutics, 2024 - mdpi.com
Chagas disease and leishmaniasis are both neglected tropical diseases that affect millions of people around the world. Leishmaniasis is currently the second most widespread vector …
R Ochoa, A Ortega-Pajares, FA Castello, F Serral… - Biomolecules, 2021 - mdpi.com
Leishmaniasis is a public health disease that requires the development of more effective treatments and the identification of novel molecular targets. Since blocking the PI3K/AKT …
AL Urakov, PD Shabanov - Reviews on Clinical …, 2023 - journals.eco-vector.com
It is reported that the traditional scheme of finding and developing a new drug and conducting the whole complex of preclinical studies requires several thousand chemical …