In leprosy, classic diagnostic tools based on bacillary counts and histopathology have been
facing hurdles, especially in distinguishing latent infection from active disease and …

Molecular epidemiology investigations are notoriously challenging in the leprosy field
mainly because the inherent characteristics of the disease as well as its yet uncultivated …

Skin biopsy samples from 145 relapse leprosy cases and from five different regions in Brazil
were submitted for sequence analysis of part of the genes associated with Mycobacterium …

Background Since leprosy is both treated and controlled by multidrug therapy (MDT) it is
important to monitor recurrent cases for drug resistance and to distinguish between relapse …

Abstract Background The fact that Mycobacterium leprae does not grow in vitro remains a
challenge in the survey of its antimicrobial resistance (AMR). Mainly molecular methods are …

The World Health Organization has raised concerns about the increasing number of Hansen
disease (HD) relapses worldwide, especially in Brazil, India, and Indonesia that report the …

Background Previous studies of drug resistance have shown that mutations in the drug
resistance‐determining region (DRDR) in the Folp1, RpoB and GyrA genes of …

Objectives: To determine the frequency and factors associated with relapse in multibacillary
leprosy. Design: We performed a retrospective cohort study on multibacillary leprosy …

Leprosy is endemic in large part of Brazil with 28,761 new patients in 2015, the second
largest number worldwide and reaches 9/10.000 in highly endemic regions and 2.7/10.000 …

We analysed 16 variable number tandem repeats (VNTR) and three single-nucleotide
polymorphisms (SNP) in Mycobacterium leprae present on 115 Ziehl-Neelsen (ZN)-stained …