This review article provides a historical perspective on the role of purinergic signalling in the
regulation of various subsets of immune cells from early discoveries to current …

The mechanisms of chronic infections caused by opportunistic pathogens are of keen
interest to both researchers and health professionals globally. Typically, chronic infectious …

Although extracellular ATP is abundant at sites of inflammation, its role in activating
inflammasome signalling in neutrophils is not well characterized. In the current study, we …

Extracellular ATP and related nucleotides promote a wide range of pathophysiological
responses via activation of cell surface purinergic P2 receptors. Almost every cell type …

Abstract The ATP receptor P2X7 (P2X7R or P2RX7) has a key role in inflammation and
immunity, but its possible roles in cancer are not firmly established. In the present study, we …

Microglial cells regulate neural homeostasis by coordinating both immune responses and
clearance of debris, and the P2X7 receptor for extracellular ATP plays a central role in both …

Porphyromonas gingivalis (P. gingivalis) and Fusobacterium nucleatum (F. nucleatum) are
Gram‐negative anaerobic bacteria possessing several virulence factors that make them …

The human P2X7 receptor is a trimeric ligand-gated cation channel coded by the P2XR7
gene located at chromosome position 12q24. P2X7 is expressed in a wide variety of normal …

Under stress, chlamydiae can enter a non-infectious but viable state termed persistence. In
the absence of a tractable genetic system, persistence induction provides an important …

P2X7 receptor, a purinergic receptor family member, is abundantly expressed on many cells,
including immune, muscle, bone, neuron, and glia. It acts as an ATP-activated cation …