Multifunctional toxins in snake venoms and therapeutic implications: from pain to hemorrhage and necrosis

CR Ferraz, A Arrahman, C Xie, NR Casewell… - Frontiers in ecology …, 2019 - frontiersin.org
Animal venoms have evolved over millions of years for prey capture and defense from
predators and rivals. Snake venoms, in particular, have evolved a wide diversity of peptides …

Haemotoxic snake venoms: their functional activity, impact on snakebite victims and pharmaceutical promise

J Slagboom, J Kool, RA Harrison… - British journal of …, 2017 - Wiley Online Library
Snake venoms are mixtures of numerous proteinacious components that exert diverse
functional activities on a variety of physiological targets. Because the toxic constituents …

Current treatment for venom-induced consumption coagulopathy resulting from snakebite

K Maduwage, GK Isbister - PLoS neglected tropical diseases, 2014 - journals.plos.org
Venomous snakebite is considered the single most important cause of human injury from
venomous animals worldwide. Coagulopathy is one of the commonest important systemic …

Ending the drought: new strategies for improving the flow of affordable, effective antivenoms in Asia and Africa

DJ Williams, JM Gutiérrez, JJ Calvete, W Wüster… - Journal of …, 2011 - Elsevier
The development of snake antivenoms more than a century ago should have heralded
effective treatment of the scourge of snakebite envenoming in impoverished, mostly rural …

Snake venomics of African spitting cobras: toxin composition and assessment of congeneric cross-reactivity of the pan-African EchiTAb-Plus-ICP antivenom by …

D Petras, L Sanz, A Segura, M Herrera… - Journal of proteome …, 2011 - ACS Publications
Venomic analysis of the venoms of Naja nigricollis, N. katiensis, N. nubiae, N. mossambica,
and N. pallida revealed similar compositional trends. The high content of cytotoxins and …

Old World Vipers—a review about snake venom proteomics of Viperinae and their variations

M Damm, BF Hempel, RD Süssmuth - Toxins, 2021 - mdpi.com
Fine-tuned by millions of years of evolution, snake venoms have frightened but also
fascinated humanity and nowadays they constitute potential resources for drug …

Snake venomics: from the inventory of toxins to biology

JJ Calvete - Toxicon, 2013 - Elsevier
A deep understanding of the composition of venoms and of the principles governing the
evolution of venomous systems is of applied importance for exploring the enormous …

[HTML][HTML] Snake venom cytotoxins, phospholipase A2s, and Zn2+-dependent metalloproteinases: mechanisms of action and pharmacological relevance

SE Gasanov, RK Dagda, ED Rael - Journal of clinical toxicology, 2014 - ncbi.nlm.nih.gov
Snake venom toxins are responsible for causing severe pathology and toxicity following
envenomation including necrosis, apoptosis, neurotoxicity, myotoxicity, cardiotoxicity …

Snakebite: When the human touch becomes a bad touch

BG Fry - Toxins, 2018 - mdpi.com
Many issues and complications in treating snakebite are a result of poor human social,
economic and clinical intervention and management. As such, there is scope for significant …

Intrageneric cross-reactivity of monospecific rabbit antisera against venoms of the medically most important Naja spp. African snakes

A Gómez, A Sánchez, G Durán, M Villalta… - PLOS Neglected …, 2023 - journals.plos.org
Background Envenomations by African snakes represent a high burden in the sub-Sahara
region. The design and fabrication of polyspecific antivenoms with a broader effectiveness …