Metabolic control of cell death
Background For several decades, intermediate metabolism and signal transduction have
been considered two independent entities. On one side stood the catabolic and anabolic …
been considered two independent entities. On one side stood the catabolic and anabolic …
Bax/Bcl-2 cascade is regulated by the EGFR pathway: therapeutic targeting of non-small cell lung cancer
Non-small cell lung carcinoma (NSCLC) comprises 80%–85% of lung cancer cases. EGFR
is involved in several cancer developments, including NSCLC. The EGFR pathway …
is involved in several cancer developments, including NSCLC. The EGFR pathway …
Metabolic implications of organelle–mitochondria communication
I Gordaliza‐Alaguero, C Cantó, A Zorzano - EMBO reports, 2019 - embopress.org
Cellular organelles are not static but show dynamism—a property that is likely relevant for
their function. In addition, they interact with other organelles in a highly dynamic manner. In …
their function. In addition, they interact with other organelles in a highly dynamic manner. In …
Modulation of the apoptosis gene Bcl-x function through alternative splicing
M Stevens, S Oltean - Frontiers in Genetics, 2019 - frontiersin.org
Apoptosis plays a vital role in cell homeostasis during development and disease. Bcl-x, a
member of the Bcl-2 family of proteins, is a mitochondrial transmembrane protein that …
member of the Bcl-2 family of proteins, is a mitochondrial transmembrane protein that …
[HTML][HTML] Apoptosis in pancreatic β-islet cells in Type 2 diabetes
T Tomita - Bosnian journal of basic medical sciences, 2016 - ncbi.nlm.nih.gov
Apoptosis plays important roles in the pathophysiology of Type 2 diabetes mellitus (T2DM).
The etiology of T2DM is multifactorial, including obesity-associated insulin resistance …
The etiology of T2DM is multifactorial, including obesity-associated insulin resistance …
Mitigating hypoxic stress on pancreatic islets via in situ oxygen generating biomaterial
MM Coronel, R Geusz, CL Stabler - Biomaterials, 2017 - Elsevier
A major obstacle in the survival and efficacy of tissue engineered transplants is inadequate
oxygenation, whereby unsupportive oxygen tensions result in significant cellular dysfunction …
oxygenation, whereby unsupportive oxygen tensions result in significant cellular dysfunction …
Bcl-XL: a multifunctional anti-apoptotic protein
M Li, D Wang, J He, L Chen, H Li - Pharmacological research, 2020 - Elsevier
B-cell lymphoma-extra large (Bcl-X L) is one of the anti-apoptotic proteins of the Bcl-2 family
that is localized in the mitochondria. Bcl-X L is one of the key regulators of apoptosis that can …
that is localized in the mitochondria. Bcl-X L is one of the key regulators of apoptosis that can …
MicroRNA 21 targets BCL2 mRNA to increase apoptosis in rat and human beta cells
Aims/hypothesis The role of beta cell microRNA (miR)-21 in the pathophysiology of type 1
diabetes has been controversial. Here, we sought to define the context of beta cell miR-21 …
diabetes has been controversial. Here, we sought to define the context of beta cell miR-21 …
Potential Effects of Sweet Potato (Ipomoea batatas) in Hyperglycemia and Dyslipidemia—A Systematic Review in Diabetic Retinopathy Context
Hyperglycemia is a condition with high glucose levels that may result in dyslipidemia. In
severe cases, this alteration may lead to diabetic retinopathy. Numerous drugs have been …
severe cases, this alteration may lead to diabetic retinopathy. Numerous drugs have been …
Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci
GA Walford, S Gustafsson, D Rybin, A Stančáková… - Diabetes, 2016 - Am Diabetes Assoc
Genome-wide association studies (GWAS) have found few common variants that influence
fasting measures of insulin sensitivity. We hypothesized that a GWAS of an integrated …
fasting measures of insulin sensitivity. We hypothesized that a GWAS of an integrated …