Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Changes in the properties and postsynaptic abundance of AMPA-type glutamate receptors
(AMPARs) are major mechanisms underlying various forms of synaptic plasticity, including …

AMPA receptors (AMPARs) are assemblies of four core subunits, GluA1–4, that mediate
most fast excitatory neurotransmission. The component subunits determine the functional …

In the mammalian central nervous system, excitatory glutamatergic synapses harness
neurotransmission that is mediated by ion flow through α-amino-3-hydroxy-5-methyl-4 …

AMPA receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in
the brain. Dynamic changes in neuronal synaptic efficacy, termed synaptic plasticity, are …

Homeostatic synaptic scaling is a form of synaptic plasticity that adjusts the strength of all of
a neuron's excitatory synapses up or down to stabilize firing. Current evidence suggests that …

The ability to change behavior likely depends on the selective strengthening and weakening
of brain synapses. The cellular models of synaptic plasticity, long-term potentiation (LTP) …

Abstract N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP)
and long-term depression (LTD) of signal transmission form neural circuits and thus are …

In the nervous system, many intracellular responses to elevated calcium are mediated by
CaM kinases (CaMKs), a family of protein kinases whose activities are initially modulated by …

Information processing in the brain requires multiple forms of synaptic plasticity that
converge on regulation of NMDA and AMPA-type glutamate receptors (NMDAR, AMPAR) …