Synthetic living materials in cancer biology
Living materials, which are made either of or by living cells, or are synthetic materials with
programmable elements catered to cells, are environmentally responsive and can self …
programmable elements catered to cells, are environmentally responsive and can self …
Engineering approaches for RNA-based and cell-based osteoarthritis therapies
Osteoarthritis (OA) is a chronic, debilitating disease that substantially impairs the quality of
life of affected individuals. The underlying mechanisms of OA are diverse and are becoming …
life of affected individuals. The underlying mechanisms of OA are diverse and are becoming …
Engineering programmable material-to-cell pathways via synthetic notch receptors to spatially control differentiation in multicellular constructs
Synthetic Notch (synNotch) receptors are genetically encoded, modular synthetic receptors
that enable mammalian cells to detect environmental signals and respond by activating user …
that enable mammalian cells to detect environmental signals and respond by activating user …
Robust tissue pattern formation by coupling morphogen signal and cell adhesion
K Mizuno, T Hirashima, S Toda - EMBO reports, 2024 - embopress.org
Morphogens, locally produced signaling molecules, form a concentration gradient to guide
tissue patterning. Tissue patterns emerge as a collaboration between morphogen diffusion …
tissue patterning. Tissue patterns emerge as a collaboration between morphogen diffusion …
Adult tissue-specific stem cell interaction: novel technologies and research advances
X Luo, Z Liu, R Xu - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
Adult tissue-specific stem cells play a dominant role in tissue homeostasis and regeneration.
Various in vivo markers of adult tissue-specific stem cells have been increasingly reported …
Various in vivo markers of adult tissue-specific stem cells have been increasingly reported …
New tricks for an old pathway: emerging Notch-based biotechnologies and therapeutics
The Notch pathway regulates a diverse array of cell fate decisions, making it an enticing
target in cancer therapy and regenerative medicine. During the early stages of Notch drug …
target in cancer therapy and regenerative medicine. During the early stages of Notch drug …
Fluorescein-based SynNotch adaptors for regulating gene expression responses to diverse extracellular and matrix-based cues
JC Tran, CJ Kuffner, AM Marzilli, RE Miller… - Nature …, 2025 - nature.com
Abstract Synthetic Notch (SynNotch) receptors function like natural Notch proteins and can
be used to install customized sense-and-respond capabilities into mammalian cells. Here …
be used to install customized sense-and-respond capabilities into mammalian cells. Here …
Use of CRISPRoff and synthetic Notch to modulate and relay endogenous gene expression programs in engineered cells
S Shi, CA Hamann, JC Lee, JM Brunger - Frontiers in Bioengineering …, 2024 - frontiersin.org
Uncovering the stimulus-response histories that give rise to cell fates and behaviors is an
area of great interest in developmental biology, tissue engineering, and regenerative …
area of great interest in developmental biology, tissue engineering, and regenerative …
[HTML][HTML] Engineering the next generation of theranostic biomaterials with synthetic biology
Biomaterials have evolved from inert materials to responsive entities, playing a crucial role
in disease diagnosis, treatment, and modeling. However, their advancement is hindered by …
in disease diagnosis, treatment, and modeling. However, their advancement is hindered by …
Engineering programmable material-to-cell pathways via synthetic notch receptors to spatially control cellular phenotypes in multi-cellular constructs
Synthetic Notch (synNotch) receptors are modular synthetic components that are genetically
engineered into mammalian cells to detect signals presented by neighboring cells and …
engineered into mammalian cells to detect signals presented by neighboring cells and …