The exocyst is an octameric protein complex that is implicated in the tethering of secretory
vesicles to the plasma membrane prior to SNARE-mediated fusion. Spatial and temporal …

More than a hundred proteins comprise the RAS superfamily of small GTPases. This family
can be divided into RAS, RHO, RAB, RAN, ARF, and RAD subfamilies, with each shown to …

The study of macroautophagy in mammalian cells has described induction, vesicle
nucleation, and membrane elongation complexes as key signaling intermediates driving …

The exocyst is a conserved octameric complex that tethers exocytic vesicles to the plasma
membrane prior to fusion. Exocyst assembly and delivery mechanisms remain unclear …

Since their discovery in 1986, Ral (Ras-like) GTPases have emerged as critical regulators of
diverse cellular functions. Ral-selective guanine nucleotide exchange factors (RalGEFs) …

The high frequency of RAS mutations in human cancers (33%) has stimulated intense
interest in the development of anti-Ras inhibitors for cancer therapy. Currently, the major …

Abstract TANK Binding Kinase 1 (TBK1) is a non-canonical IκB kinase that contributes to
KRAS-driven lung cancer. Here we report that TBK1 plays essential roles in mammalian cell …

Abstract The Ral guanosine triphosphatases (GTPases), RalA and RalB, are members of the
Ras superfamily of small GTPases. Research on Ral GTPases and their functions over the …

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by T cell
overactivation and B cell hyper-stimulation. Hematopoietic progenitor kinase 1 (HPK1, also …

The Ras family G‐proteins RalA and RalB make critical non‐overlapping contributions to the
generation of a tumorigenic regulatory network, supporting bypass of the normal restraints …