Fanconi anaemia (FA) is the most frequent inherited bone marrow failure syndrome, due to
mutations in genes encoding proteins involved in replication fork protection, DNA interstrand …

Simple Summary Cancer cells display among its hallmark genomic instability. This is a
progressive tendency in accumulate genome alteration which contributes to the damage of …

Replication stress (RS) is a leading cause of genome instability and cancer development. A
substantial source of endogenous RS originates from the encounter between the …

Impaired replication progression leads to de novo copy number variant (CNV) formation at
common fragile sites (CFSs). We previously showed that these hotspots for genome …

Background: Induced senescence could be exploited to selectively counteract the
proliferation of cancer cells and target them for senolysis. We examined the cellular …

Members of the ubiquitin-like protein family are known for their ability to modify substrates by
covalent conjugation. The highly conserved ubiquitin relative UBL5/Hub1, however, is …

Fanconi anemia (FA) is a rare genetic disorder characterized by bone marrow failure and
aplastic anemia. So far, 23 genes are involved in this pathology, and their mutations lead to …

The amyloid precursor protein (APP) is a cell surface protein of uncertain function that is
notable for being the parent protein of beta-amyloid. Research around this protein has …

Mitochondria are highly specialised organelles required for key cellular processes including
ATP production through cellular respiration and controlling cell death via apoptosis. Unlike …

The faithful splicing of pre-mRNA is critical for accurate gene expression. Dysregulation of
pre-mRNA splicing has been associated with several human diseases including cancer. The …