Amyloid β-based therapy for Alzheimer's disease: Challenges, successes and future

Y Zhang, H Chen, R Li, K Sterling… - Signal transduction and …, 2023 - nature.com
Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

HJ Forman, H Zhang - Nature Reviews Drug Discovery, 2021 - nature.com
Oxidative stress is a component of many diseases, including atherosclerosis, chronic
obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small …

Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer's disease

WD Bao, P Pang, XT Zhou, F Hu, W Xiong… - Cell Death & …, 2021 - nature.com
Iron homeostasis disturbance has been implicated in Alzheimer's disease (AD), and excess
iron exacerbates oxidative damage and cognitive defects. Ferroptosis is a nonapoptotic form …

Reactive oxygen species (ROS)-based nanomedicine

B Yang, Y Chen, J Shi - Chemical reviews, 2019 - ACS Publications
Reactive oxygen species (ROS) play an essential role in regulating various physiological
functions of living organisms. The intrinsic biochemical properties of ROS, which underlie …

History and progress of hypotheses and clinical trials for Alzheimer's disease

PP Liu, Y Xie, XY Meng, JS Kang - Signal transduction and targeted …, 2019 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its …

The essential elements of Alzheimer's disease

P Lei, S Ayton, AI Bush - Journal of Biological Chemistry, 2021 - ASBMB
Treatments for Alzheimer's disease (AD) directed against the prominent amyloid plaque
neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are …

[HTML][HTML] Oxidative stress and the amyloid beta peptide in Alzheimer's disease

C Cheignon, M Tomas, D Bonnefont-Rousselot… - Redox biology, 2018 - Elsevier
Oxidative stress is known to play an important role in the pathogenesis of a number of
diseases. In particular, it is linked to the etiology of Alzheimer's disease (AD), an age-related …

Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases

T Nakamura, I Naguro, H Ichijo - Biochimica et Biophysica Acta (BBA) …, 2019 - Elsevier
Background Iron is essential for many types of biological processes. However, excessive
iron can be cytotoxic and can lead to many diseases. Since ferroptosis, which is an iron …

Oxidative stress occurs prior to amyloid Aβ plaque formation and tau phosphorylation in Alzheimer's disease: Role of glutathione and metal ions

RG Roy, PK Mandal, JC Maroon - ACS Chemical Neuroscience, 2023 - ACS Publications
Alzheimer's disease (AD) is an insidious and progressive neurodegenerative disorder that
affects millions of people worldwide. Although the pathogenesis remains obscure, there are …

Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease

M Jakaria, AA Belaidi, AI Bush… - Journal of …, 2021 - Wiley Online Library
Alzheimer's disease (AD) is the most prevalent form of dementia, with complex
pathophysiology that is not fully understood. While β‐amyloid plaque and neurofibrillary …