Background Non‐invasive ventilation may be a means to temporarily reverse or slow the
progression of respiratory failure in cystic fibrosis by providing ventilatory support and …

Most of the morbidity and mortality in cystic fibrosis (CF) results from its pulmonary
manifestations. The CF lung is susceptible to endobronchial bacterial infection, which …

This thoroughly revised and expanded reference provides authoritative discussions on the
physiologic, pharmacologic, metabolic, molecular, cellular and physicochemical factors …

Pressurized metered-dose inhalers (pMDIs) and nebulizers are routinely employed for
aerosol delivery in mechanically ventilated patients. A significant proportion of the aerosol …

In selected patients, noninvasive positive pressure ventilation (NIPPV) with a facemask is
now commonly employed as the first choice for providing mechanical ventilation in the …

Objective Respiratory failure due to exacerbation of obstructive lung disease has been
successfully treated with noninvasive positive pressure ventilation (NPPV). However, there …

Purpose Unlike in the outpatient setting, delivery of aerosols to critically ill patients may be
considered complex, particularly in ventilated patients, and benefits remain to be proven …

Chronic neutrophilic inflammation leads to oxidative damage, which may play an important
role in the pathogenesis of cystic fibrosis lung disease. Bronchoalveolar lavage levels of the …

Pressurized metered-dose inhalers (pMDIs) and nebulizers are employed routinely for
aerosol delivery to ventilator-supported patients, but the ventilator circuit and artificial airway …