The ability of an epithelium to prevent permeation of noxious agents has not been well
studied except in the gastrointestinal tract where exclusion of H+ has clinical significance …

The introduction of the concept of blood-ocular barriers in the ophthalmic literature is briefly
reviewed. Two main blood-ocular barriers are proposed: the blood-aqueous barrier and the …

Fractionation of MOPC 41 DL-1 tumors revealed that the mRNA for the light chain of
immunoglobulin is localized exclusively in membrane-bound ribosomes. It was shown that …

Crystal structures of the amino-terminal domain of N-cadherin provide a picture at the atomic
level of a specific adhesive contact between cells. A repeated set of dimer interfaces is …

Adherens junctions, which play a central role in intercellular adhesion, comprise clusters of
type I classical cadherins that bind via extracellular domains extended from opposing cell …

The structural basis of the permeability barrier in mammalian epidermis was examined by
tracer and freeze-fracture techniques. Water-soluble tracers (horesradish peroxidase …

Cells in organs and tissues, it is now well established, make permeable junctions that
provide a path for direct flow of molecules between cell interiors. Ever since the nearly …

Adhesion between cells is essential to the evolution of multicellularity. Indeed,
morphogenesis in animals requires firm but flexible intercellular adhesions that are …

Publisher Summary Intercellular junctions are specialized regions of contact between the
apposed plasma membranes of adjacent cells, and recent evidence suggests that they are …

An overwhelming amount of data has imphcated the cell surface as the primary s~ te for
control of cell growth, dwlslon, development, commumcatlon, differentiation and death. Cells …