Effects of SGLT2 inhibitors on systemic and tissue low-grade inflammation: the potential contribution to diabetes complications and cardiovascular disease

F Bonnet, AJ Scheen - Diabetes & metabolism, 2018 - Elsevier
Chronic low-grade inflammation is a recognized key feature associated with type 2 diabetes
mellitus (T2DM) and its complications. In prospective randomized trials, sodium-glucose …

Obesity: systemic and pulmonary complications, biochemical abnormalities, and impairment of lung function

TT Mafort, R Rufino, CH Costa, AJ Lopes - Multidisciplinary respiratory …, 2016 - Springer
Obesity is currently one of the major epidemics of this millennium and affects individuals
throughout the world. It causes multiple systemic complications, some of which result in …

Weight loss is a critical factor to reduce inflammation

VE Bianchi - Clinical nutrition ESPEN, 2018 - Elsevier
Background Chronic inflammation is a process sustained by the augmentation of circulating
cytokines level and C-reactive protein (CRP). Adipocytes and adipose tissue infiltration with …

Role of oxylipins in cardiovascular diseases

MA Nayeem - Acta Pharmacologica Sinica, 2018 - nature.com
Globally, cardiovascular diseases (CVDs) are the number one cause of mortality.
Approximately 18 million people died from CVDs in 2015, representing more than 30% of all …

Potential impact of nutrition on immune system recovery from heavy exertion: a metabolomics perspective

DC Nieman, SH Mitmesser - Nutrients, 2017 - mdpi.com
This review describes effective and ineffective immunonutrition support strategies for the
athlete, with a focus on the benefits of carbohydrates and polyphenols as determined from …

Dietary modulation of oxylipins in cardiovascular disease and aging

SPB Caligiuri, M Parikh… - American Journal …, 2017 - journals.physiology.org
Oxylipins are a group of fatty acid metabolites generated via oxygenation of polyunsaturated
fatty acids and are involved in processes such as inflammation, immunity, pain, vascular …

MS-based targeted metabolomics of eicosanoids and other oxylipins: Analytical and inter-individual variabilities

C Gladine, AI Ostermann, JW Newman… - Free Radical Biology and …, 2019 - Elsevier
Oxylipins, including the well-known eicosanoids, are potent lipid mediators involved in
numerous physiological and pathological processes. Therefore, their quantitative profiling …

Obesity is positively associated with arachidonic acid-derived 5-and 11-hydroxyeicosatetraenoic acid (HETE)

CA Pickens, LM Sordillo, C Zhang, JI Fenton - Metabolism, 2017 - Elsevier
Background Oxylipids are oxygenated polyunsaturated fatty acid (PUFA) metabolites that
are responsible for the onset and resolution of the inflammatory response. Enzymatic …

Alterations of specific lipid groups in serum of obese humans: a review

A Mika, T Sledzinski - Obesity Reviews, 2017 - Wiley Online Library
Obesity is a major contributor to the dysfunction of liver, cardiac, pulmonary, endocrine and
reproductive system, as well as a component of metabolic syndrome. Although development …

Effect of a long-term intensive lifestyle intervention on prevalence of cognitive impairment

MA Espeland, JA Luchsinger, LD Baker, R Neiberg… - Neurology, 2017 - AAN Enterprises
Objective: To assess whether an average of 10 years of lifestyle intervention designed to
reduce weight and increase physical activity lowers the prevalence of cognitive impairment …