Copper toxicity links to pathogenesis of Alzheimer's disease and therapeutics approaches

HW Ejaz, W Wang, M Lang - International Journal of Molecular Sciences, 2020 - mdpi.com
Alzheimer's disease (AD) is an irreversible, age-related progressive neurological disorder,
and the most common type of dementia in aged people. Neuropathological lesions of AD …

A closer look at amyloid ligands, and what they tell us about protein aggregates

TS Chisholm, CA Hunter - Chemical Society Reviews, 2024 - pubs.rsc.org
The accumulation of amyloid fibrils is characteristic of neurodegenerative diseases such as
Alzheimer's disease (AD) and Parkinson's disease. Detecting these fibrils with fluorescent or …

Novel Benzothiazole-Based Highly Selective Ratiometric Fluorescent Turn-On Sensors for Zn2+ and Colorimetric Chemosensors for Zn2+, Cu2+, and Ni2+ Ions

CAS Pothulapadu, A Jayaraj, SN, RN Priyanka… - ACS …, 2021 - ACS Publications
Metal ions play a very important role in environmental as well as biological fields. The
detection of specific metal ions at a minute level caught much attention, and hence, several …

Amphiphilic distyrylbenzene derivatives as potential therapeutic and imaging agents for soluble and insoluble amyloid β aggregates in Alzheimer's disease

L Sun, HJ Cho, S Sen, AS Arango… - Journal of the …, 2021 - ACS Publications
Alzheimer's Disease (AD) is the most common neurodegenerative disease, and efficient
therapeutic and early diagnostic agents for AD are still lacking. Herein, we report the …

Cu and Zn interactions with Aβ peptides: consequence of coordination on aggregation and formation of neurotoxic soluble Aβ oligomers

M Rana, AK Sharma - Metallomics, 2019 - academic.oup.com
The coordination chemistry of transition metal ions (Fe, Cu, Zn) with the amyloid-β (Aβ)
peptides has attracted a lot of attention in recent years due to its repercussions in …

Multi-target-directed phenol–triazole ligands as therapeutic agents for Alzheimer's disease

MR Jones, E Mathieu, C Dyrager, S Faissner… - Chemical …, 2017 - pubs.rsc.org
Alzheimer's disease (AD) is a multifactorial disease that is characterized by the formation of
intracellular neurofibrillary tangles and extracellular amyloid-β (Aβ) plaque deposits …

Synthesis and biological evaluation of deferiprone-resveratrol hybrids as antioxidants, Aβ1–42 aggregation inhibitors and metal-chelating agents for Alzheimer's …

P Xu, M Zhang, R Sheng, Y Ma - European journal of medicinal chemistry, 2017 - Elsevier
A series of deferiprone-resveratrol hybrids have been designed and synthesized as
multitarget-directed ligands (MTDLs) through merging the chelating moiety 3-hydroxypyridin …

Metal-chelating benzothiazole multifunctional compounds for the modulation and 64 Cu PET imaging of Aβ aggregation

Y Huang, HJ Cho, N Bandara, L Sun, D Tran… - Chemical …, 2020 - pubs.rsc.org
While Alzheimer's Disease (AD) is the most common neurodegenerative disease, there is
still a dearth of efficient therapeutic and diagnostic agents for this disorder. Reported herein …

Evaluation of 64Cu-Based Radiopharmaceuticals that Target Aβ Peptide Aggregates as Diagnostic Tools for Alzheimer's Disease

N Bandara, AK Sharma, S Krieger… - Journal of the …, 2017 - ACS Publications
Positron emission tomography (PET) imaging agents that detect amyloid plaques containing
amyloid beta (Aβ) peptide aggregates in the brain of Alzheimer's disease (AD) patients have …

Antioxidant and copper-chelating power of new molecules suggested as multiple target agents against Alzheimer's disease. A theoretical comparative study

M Spiegel, T Marino, M Prejanò… - Physical Chemistry …, 2022 - pubs.rsc.org
In this study, the scavenging activity against OOH radicals and the copper-chelating ability of
two new synthesized molecules (named L1 and L2) that can act as multiple target agents …