Aging and vascular endothelial function in humans

DR Seals, KL Jablonski, AJ Donato - Clinical science, 2011 - portlandpress.com
Advancing age is the major risk factor for the development of CVD (cardiovascular
diseases). This is attributable, in part, to the development of vascular endothelial …

Long term hormone therapy for perimenopausal and postmenopausal women

J Marjoribanks, C Farquhar, H Roberts… - … of systematic reviews, 2012 - cochranelibrary.com
Background Hormone therapy (HT) is widely used for controlling menopausal symptoms
and has also been used for the management and prevention of cardiovascular disease …

Estrogen and the cardiovascular system

AA Knowlton, AR Lee - Pharmacology & therapeutics, 2012 - Elsevier
Estrogen is a potent steroid with pleiotropic effects, which have yet to be fully elucidated.
Estrogen has both nuclear and non-nuclear effects. The rapid response to estrogen, which …

Meta‐analysis: effect of hormone‐replacement therapy on components of the metabolic syndrome in postmenopausal women

SR Salpeter, JME Walsh, TM Ormiston… - Diabetes, Obesity …, 2006 - Wiley Online Library
Aim: To quantify the effects of hormone‐replacement therapy (HRT) on components of the
metabolic syndrome in postmenopausal women. Methods: Comprehensive searches of …

Estrogen modulation of endothelial nitric oxide synthase

KL Chambliss, PW Shaul - Endocrine reviews, 2002 - academic.oup.com
Over the past decade, clinical and basic research has demonstrated that estrogen has a
dramatic impact on the response to vascular injury and the development of atherosclerosis …

Raloxifene and cardiovascular events in osteoporotic postmenopausal women: four-year results from the MORE (Multiple Outcomes of Raloxifene Evaluation) …

E Barrett-Connor, D Grady, A Sashegyi, PW Anderson… - Jama, 2002 - jamanetwork.com
ContextRaloxifene, a selective estrogen receptor modulator, improves cardiovascular risk
factors, but its effect on cardiovascular events is unknown. ObjectiveTo determine the effect …

Aging women and their endothelium: probing the relative role of estrogen on vasodilator function

YB Somani, JA Pawelczyk… - American Journal …, 2019 - journals.physiology.org
Despite significant decreases in cardiovascular disease (CVD) mortality in the past three
decades, it still remains the leading cause of death in women. Following menopause and …

Gender differences in advanced heart failure: insights from the BEST study

JK Ghali, HJ Krause-Steinrauf, KF Adams… - Journal of the American …, 2003 - jacc.org
Objectives: The goal of this study was to determine the influence of gender on baseline
characteristics, response to treatment, and prognosis in patients with heart failure (HF) and …

Clinical efficacy of cardiac resynchronization therapy using left ventricular pacing in heart failure patients stratified by severity of ventricular conduction delay

A Auricchio, C Stellbrink, C Butter, S Sack… - Journal of the American …, 2003 - jacc.org
Objectives: We assessed the clinical efficacy of single-site left ventricular (LV) pacing and
determined the impact of baseline conduction delay severity on the magnitude of benefit …

Mortality associated with hormone replacement therapy in younger and older women: a meta‐analysis

SR Salpeter, JME Walsh, E Greyber… - Journal of general …, 2004 - Wiley Online Library
OBJECTIVE: To assess mortality associated with hormone replacement in younger and
older postmenopausal women. DESIGN: A comprehensive search of medline, cinahl, and …