Bipolar disorder (BD) is one of the most heritable mental illnesses, but the elucidation of its
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …

Background Completed suicide is a major cause of death in bipolar disorder (BD) patients.
Objective The aim of this paper is to provide an overall review of the existing literature of …

Background Major depression is a disabling psychiatric illness with complex origins. Life
stress (childhood adversity and recent stressful events) is a robust risk factor for depression …

To identify bipolar disorder (BD) genetic susceptibility factors, we conducted two genome-
wide association (GWA) studies: one involving a sample of individuals of European ancestry …

Neurons have highly developed Ca 2+ signalling systems responsible for regulating many
neural functions such as the generation of brain rhythms, information processing and the …

Objective: The singular phenomenon of switching from depression to its opposite state of
mania or hypomania, and vice versa, distinguishes bipolar disorder from all other psychiatric …

The regulation of the brain-derived neurotrophic factor (BDNF) is important for depression
pathophysiology and epigenetic regulation of the BDNF gene may be involved. This study …

Given the mounting convergent evidence implicating many more genes in complex
disorders such as bipolar disorder than the small number identified unambiguously by the …

Categorization of psychotic illnesses into schizophrenic and affective psychoses remains an
ongoing controversy. Although Kraepelinian subtyping of psychosis was historically …

Brain-derived neurotrophic factor (BDNF) gene regulation has been linked to the
pathophysiology of major depressive disorder (MDD). MDD patients show cognitive deficits …