Immunotherapy strategies against cancer are emerging as powerful weapons for treatment
of this disease. The success of checkpoint inhibitors against metastatic melanoma and …

Natural killer (NK) cells constitute a minor subset of normal lymphocytes that initiate innate
immune responses toward tumor and virus-infected cells. They can mediate spontaneous …

One important purpose of T cell engineering is to generate tumor-targeted T cells through
the genetic transfer of antigen-specific receptors, which consist of either physiological, MHC …

The MHC-I antigen presentation (AP) pathway is key to shaping mammalian CD8+ T cell
immunity, with its aberrant expression closely linked to low tumor immunogenicity and …

Chimeric antigen receptor (CAR) T cells are a rapidly emerging form of cancer treatment,
and have resulted in remarkable responses in refractory lymphoid malignancies. However …

The initiation, magnitude and duration of an immune response against antigens are a tightly
regulated process involving a dynamic, orchestrated balance of pro-and anti-inflammatory …

Natural killer (NK) cells play a significant role in immune tolerance and immune surveillance.
Killer immunoglobin-like receptors (KIRs), which recognize human leukocyte antigen (HLA) …

Most human papillomaviruses cause inapparent infections, subtly affecting epithelial
homeostasis, to ensure genome persistence in the epithelial basal layer. As with …

HLA class I loss is a significant mechanism of immune evasion by cervical carcinoma,
interfering with the development of immunotherapies and cancer vaccines. We report the …

Background Trastuzumab is a monoclonal antibody selectively directed against Her2 and
approved for the treatment of Her2 overexpressing breast cancer patients. Its proposed …