Discovering riboswitches: the past and the future

K Kavita, RR Breaker - Trends in biochemical sciences, 2023 - cell.com
Riboswitches are structured noncoding RNA domains used by many bacteria to monitor the
concentrations of target ligands and regulate gene expression accordingly. In the past 20 …

Electron transfer beyond the outer membrane: putting electrons to rest

JA Gralnick, DR Bond - Annual Review of Microbiology, 2023 - annualreviews.org
Extracellular electron transfer (EET) is the physiological process that enables the reduction
or oxidation of molecules and minerals beyond the surface of a microbial cell. The first …

Cyclic di-GMP: second messenger extraordinaire

U Jenal, A Reinders, C Lori - Nature Reviews Microbiology, 2017 - nature.com
Cyclic dinucleotides (CDNs) are highly versatile signalling molecules that control various
important biological processes in bacteria. The best-studied example is cyclic di-GMP (c-di …

The biochemical landscape of riboswitch ligands

RR Breaker - Biochemistry, 2022 - ACS Publications
More than 55 distinct classes of riboswitches that respond to small metabolites or elemental
ions have been experimentally validated to date. The ligands sensed by these riboswitches …

Riboswitch diversity and distribution

PJ McCown, KA Corbino, S Stav, ME Sherlock… - Rna, 2017 - rnajournal.cshlp.org
Riboswitches are commonly used by bacteria to detect a variety of metabolites and ions to
regulate gene expression. To date, nearly 40 different classes of riboswitches have been …

Comparative genomic analyses reveal a vast, novel network of nucleotide-centric systems in biological conflicts, immunity and signaling

AM Burroughs, D Zhang, DE Schäffer… - Nucleic acids …, 2015 - academic.oup.com
Cyclic di-and linear oligo-nucleotide signals activate defenses against invasive nucleic
acids in animal immunity; however, their evolutionary antecedents are poorly understood …

The electrifying physiology of Geobacter bacteria, 30 years on

G Reguera, K Kashefi - Advances in microbial physiology, 2019 - Elsevier
The family Geobacteraceae, with its only valid genus Geobacter, comprises
deltaproteobacteria ubiquitous in soil, sediments, and subsurface environments where metal …

Engineering and in vivo applications of riboswitches

ZF Hallberg, Y Su, RZ Kitto… - Annual review of …, 2017 - annualreviews.org
Riboswitches are common gene regulatory units mostly found in bacteria that are capable of
altering gene expression in response to a small molecule. These structured RNA elements …

RNA structure and cellular applications of fluorescent light‐up aptamers

S Neubacher, S Hennig - Angewandte Chemie International …, 2019 - Wiley Online Library
The cellular functions of RNA are not limited to their role as blueprints for protein synthesis.
In particular, noncoding RNA, such as, snRNAs, lncRNAs, miRNAs, play important roles …

Bacterial signal transduction by cyclic di-GMP and other nucleotide second messengers

R Hengge, A Gründling, U Jenal, R Ryan… - Journal of …, 2016 - Am Soc Microbiol
ABSTRACT The first International Symposium on c-Di-GMP Signaling in Bacteria (22 to 25
March 2015, Harnack-Haus, Berlin, Germany) brought together 131 molecular …