Adipose tissue, colloquially known as" fat," is an extraordinarily flexible and heterogeneous
organ. While historically viewed as a passive site for energy storage, we now appreciate that …

The perception that intracellular lipolysis is a straightforward process that releases fatty
acids from fat stores in adipose tissue to generate energy has experienced major revisions …

Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …

Mammalian target of rapamycin (mTOR), a serine/threonine protein kinase and a master
regulator of cell growth and metabolism, forms two structurally and functionally distinct …

The mechanistic target of rapamycin (mTOR) has gathered significant attention as a
ubiquitously expressed multimeric kinase with key implications for cell growth, proliferation …

The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

Background The diminished glucose lowering effect of insulin in obesity, called “insulin
resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious …

Cancer cells support their growth and proliferation by reprogramming their metabolism in
order to gain access to nutrients. Despite the heterogeneity in genetic mutations that lead to …

The protein kinase mechanistic target of rapamycin (mTOR) functions as a central regulator
of metabolism, integrating diverse nutritional and hormonal cues to control anabolic …