Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity
Summary Relatlimab (rela; anti-LAG-3) plus nivolumab (nivo; anti-PD-1) is safe and effective
for treatment of advanced melanoma. We designed a trial (NCT03743766) where advanced …
for treatment of advanced melanoma. We designed a trial (NCT03743766) where advanced …
SARS-CoV-2 in Danish mink farms: course of the epidemic and a descriptive analysis of the outbreaks in 2020
A Boklund, AS Hammer, ML Quaade, TB Rasmussen… - Animals, 2021 - mdpi.com
Simple Summary Since 2019, SARS-CoV-2 has spread and become a global pandemic.
Unexpectedly, infection of farmed mink by SARS-CoV-2 was detected in the Netherlands in …
Unexpectedly, infection of farmed mink by SARS-CoV-2 was detected in the Netherlands in …
An anthropometric risk index based on combining height, weight, waist, and hip measurements
NY Krakauer, JC Krakauer - Journal of obesity, 2016 - Wiley Online Library
Body mass index (BMI) can be considered an application of a power law model to express
body weight independently of height. Based on the same power law principle, we previously …
body weight independently of height. Based on the same power law principle, we previously …
Multivariable models of outcomes with [177Lu] Lu-PSMA-617: analysis of the phase 3 VISION trial
Summary Background [177 Lu] Lu-PSMA-617 (177 Lu-PSMA-617) prolonged life in patients
with metastatic castration-resistant prostate cancer (mCRPC) in VISION (NCT03511664) …
with metastatic castration-resistant prostate cancer (mCRPC) in VISION (NCT03511664) …
Serum levels of soluble programmed death-ligand 1 (sPD-L1): A possible biomarker in predicting post-treatment outcomes in patients with early hepatocellular …
Background There have been great advances in hepatocellular carcinoma management
over the last years. However, there are still no prognostic biomarkers that can identify …
over the last years. However, there are still no prognostic biomarkers that can identify …
[HTML][HTML] Prevalence, survival analysis and multimorbidity of chronic diseases in the general veterinarian-attended horse population of the UK
The average age of the global human population is increasing, leading to increased interest
in the effects of chronic disease and multimorbidity on health resources and patient welfare …
in the effects of chronic disease and multimorbidity on health resources and patient welfare …
Predicting short-term survival after gross total or near total resection in glioblastomas by machine learning-based radiomic analysis of preoperative MRI
Simple Summary Identifying GBM patients with very short survival could contribute to
adapting the therapeutic approach. According to our results, high-precision models can be …
adapting the therapeutic approach. According to our results, high-precision models can be …
Nonparametric generalized fiducial inference for survival functions under censoring
Since the introduction of fiducial inference by Fisher in the 1930s, its application has been
largely confined to relatively simple, parametric problems. In this paper, we present what …
largely confined to relatively simple, parametric problems. In this paper, we present what …
Leptomeningeal metastases in high-grade adult glioma: development, diagnosis, management, and outcomes in a series of 34 patients
C Dardis, K Milton, L Ashby, W Shapiro - Frontiers in neurology, 2014 - frontiersin.org
Methods: Leptomeningeal metastases (LM) in the setting of glioma have often been thought
to carry a particularly poor prognosis. We sought to better characterize this phenomenon …
to carry a particularly poor prognosis. We sought to better characterize this phenomenon …
Treatment reducing endothelial activation protects against experimental cerebral malaria
S Mota, J Bensalel, DH Park, S Gonzalez, A Rodriguez… - Pathogens, 2022 - mdpi.com
Cerebral malaria (CM) is the most severe neurological complication of malaria caused by
Plasmodium falciparum infection. The available antimalarial drugs are effective at clearing …
Plasmodium falciparum infection. The available antimalarial drugs are effective at clearing …