Postoperative radiotherapy, which forms part of breastconserving therapy, may not need to
encompass the whole breast. Apart from the consumption of huge resources and patients' …

Missense variants in the BRCA 2 gene are routinely detected during clinical screening for
pathogenic mutations in patients with a family history of breast and ovarian cancer. These …

PURPOSE To develop recommendations for management of patients with breast cancer
(BC) with germline mutations in BC susceptibility genes. METHODS The American Society …

Purpose We compared the outcome of breast-conserving surgery and radiotherapy in
BRCA1/2 mutation carriers with breast cancer versus that of matched sporadic controls …

Background: Second malignant neoplasms may be a consequence of radiotherapy for the
treatment of breast cancer. Prior studies evaluating sarcomas as second malignant …

Purpose: The purpose of this study was to classify all ipsilateral breast tumor relapses (IBTR)
in patients treated with conservative surgery and radiation therapy (CS+ RT) as either new …

Background Management of early-stage breast cancer in young women with mutations in
BRCA1 or BRCA2 remains controversial. This study assessed the long-term risks of …

Background The prognostic significance of germline mutations in BRCA1 and BRCA2 in
women with breast cancer remains unclear. A combined analysis was performed to address …

PURPOSE: Recent laboratory data suggest a role for BRCA1/2 in the cellular response to
DNA damage. There is a paucity of clinical data, however, examining the effect of …

Women with BRCA1 and BRCA2 mutations have an elevated risk of breast cancer and
ovarian cancer, but also of developing second primary breast cancer. BRCA1/2 mutation …