The oligomer cascade hypothesis, which states that oligomers are the initiating pathologic
agents in Alzheimer's disease, has all but supplanted the amyloid cascade hypothesis …

Considerable progress has been recently achieved in the multiscale modeling of complex
biological processes. Multiscale models have now investigated the structure and dynamics …

As was noted in our recent review, 1 the protein folding field underwent a cyclic
development. Initially, protein folding was viewed as a strictly experimental field belonging to …

Quantitative understanding of the kinetics of fibril formation and the molecular mechanism of
transition from monomers to fibrils is needed to obtain insights into the growth of amyloid …

The misfolding and pathological aggregation of α-synuclein forming insoluble amyloid
deposits is associated with Parkinson's disease, the second most common …

Silk fibers possess impressive mechanical properties, dependant, in part, on the crystalline β-
sheets silk II conformation. The transition to silk II from soluble silk I-like conformation in silk …

Protein aggregation involves the self-assembly of normally soluble proteins into large
supramolecular assemblies. The typical end product of aggregation is the amyloid fibril, an …

Groningen University, Groningen, Netherlands. MARTINI force field: extension to
carbohydrates We present an extension of the coarse grained (CG) MARTINI force field (1) …

We have revisited the protein coarse‐grained optimized potential for efficient structure
prediction (OPEP). The training and validation sets consist of 13 and 16 protein targets …

The OPEP coarse-grained protein model has been applied to a wide range of applications
since its first release 15 years ago. The model, which combines energetic and structural …