Increasing evidence that several drug compounds exert their effects through interactions
with multiple targets is boosting the development of research fields that challenge the data …

Peptide therapeutics are acclaimed as a promising addition to the pharmaceutical arena,
and they continue to attract interest due to their high potency, bioavailability, and fewer …

Virtual screening is increasingly being used in drug discovery programs with a growing
number of successful applications. Experimental methodologies developed to speed up the …

Nicotinic acetylcholine receptors (nAChRs) present as many different subtypes in the
nervous and immune systems, muscles and on the cells of other organs. In the immune …

The vast diversity of neuronal nicotinic acetylcholine subunits expressed in the central and
peripheral nervous systems, as well as in non-neuronal tissues, constitutes a formidable …

α-Conotoxins potently inhibit isoforms of nicotinic acetylcholine receptors (nAChRs), which
are essential for neuronal and neuromuscular transmission. They are also used as …

The term “venomics” was coined to describe the global study of venom and venom glands,
targeting comprehensive characterization of the whole toxin profile of a venomous animal by …

Marine cone snails are carnivorous gastropods that use peptide toxins called conopeptides
both as a defense mechanism and as a means to immobilize and kill their prey. These …

Conotoxins are small bioactive highly structured peptides from the venom of marine cone
snails (genus Conus). Over the past 50 million years these molluscs have developed a …

Modification of a peptide: The combination of aziridine aldehyde based peptide cyclization
and aziridine ring‐opening chemistry furnishes peptides with well‐defined secondary …