Despite recent progress in understanding the cancer genome, there is still a relative delay in
understanding the full aspects of the glycome and glycoproteome of cancer. Glycobiology …

Pancreatic ductal adenocarcinoma (PDA) is one of the deadliest cancers and is projected to
soon be the second leading cause of cancer death. Median survival of PDA patients is 6–10 …

Aberrant expression of immature truncated O-glycans is a characteristic feature observed on
virtually all epithelial cancer cells, and a very high frequency is observed in early epithelial …

Tumor cells exhibit striking changes in cell surface glycosylation as a consequence of
dysregulated glycosyltransferases and glycosidases. In particular, an increase in the …

Glycoconjugates constitute a major class of biomolecules which include glycoproteins,
glycosphingolipids and proteoglycans. Glycans are involved in several physiological and …

Activation of an aberrant glycosylation pathway in cancer cells can lead to expression of the
onco-foetal sialyl-Tn (sTn) antigen. STn is a truncated O-glycan containing a sialic acid α-2 …

The introduction of immunohistochemical techniques and monoclonal antibodies to specific
carbohydrate epitopes has made it possible to study in detail the tissue distribution of histo …

Pancreatic adenocarcinoma is a lethal disease with a 5‑year survival rate of< 5%, the lowest
of all types of cancer. The diagnosis of pancreatic cancer relies on imaging and tissue …

Sialyl-Tn antigen (STn) is a short O-glycan containing a sialic acid residue α2, 6-linked to
GalNAcα-O-Ser/Thr. The biosynthesis of STn is mediated by a specific sialyltransferase …

The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in
peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of …